Azhir Mahmood  🚀 🤖 🧬 🧠 🪐

Thanks for the interest, nice summary! It suggests connectivity is encoded either through other mechanisms in CA1 (replay, theta sequences, although given that place fields don't change, this would be a bit surprising) or just elsewhere (CA3, MEC, Subiculum, rest of the).

I'm also wondering, if someone ever finds an effect of connectivity on replay, how to disentangle a "representation" of connectivity from a simple reflection of behaviour / experience...

This is a great question that should feed into computational models. e.g. @AndrejBicanski's nice work

Would be interesting. This paper is a journal waiting to happen :-)

Thanks. Another thing I’m curious about. Is both spatial-visual and spatial-auditory information encoded in the same manner. Does this generalise beyond spatial visual representations? (Thus encoding all forms of spatial information).

I.e do dogs build olfactory spatial maps within their brain using the same mechanism.

Place cells in the hippocampus are integrating multimodal information, yes. For example place cells might orient their firing using a visual cue when its visible, but will be active in the same place if the light gets switched off. No idea about dogs ^^

That’s really helpful. So given they’re multimodal I’m assuming spatial parts of the information is stored in the place-cells and the sensory information is stored separately? — from my understanding place cells don’t encode sensory information. How do grid cells integrate?