Azhir Mahmood  🚀 🤖 🧬 🧠 🪐

It's astonishing that we were able to find therapeutically-relevant genetic discoveries within 6 months of the first ICU cases in the UK

Of course, as we say in the paper, we can't know that any of these drug predictions will actually work until we do large-scale, randomised clinical trials, such as RECOVERY

More than 1400 research staff worked on this project. We can't thank them all but @erolaPC @thefluzee @kcrawlik @l_klaric and social media hold-out Andy Bretherick worked day and night for 6 weeks to get the results out. @LeeMurphyCRF @EdinburghCRF did all lab work

@GenomiccStudy team, led by Fiona Griffiths, have suffered all year to cope with the massive surge in cases. 64 volunteers from @TheDickVet and @roslininstitute came forward to help when they were struggling.

And 2244 patients, or their relatives, agreed to contribute to a research study to help others, at one of the most difficult times in their lives.

The work was funded by @stopsepsisnow @wellcometrust @ICS_updates @UKRI_News @DHSCgovuk and carried out in partnership with @CCPUKstudy and @GenomicsEngland

Thanks for making it this far into a long thread. We now have 6685 patients in GenOMICC. But the best way to study them is to find similar people (by age/sex/ethnicity/postcode) to compare them to. If you'd be willing to help, please go to http://genomicc.org  and register

This thread is aimed at the lay public - we already reported our findings, and shared all our data, with the genetics community on 27th September. So I've glossed over some nuances which we discuss in the paper.