Alexander Bates

@as_bates

PhD student in Drosophila neuroscience at the MRC LMB, University of Cambridge

Cambridge, England
Vrijeme pridruživanja: srpanj 2016.

Medijski sadržaj

  1. 29. sij
    Odgovor korisnicima

    We then tried a challenging test. Third-order ‘LHNs’ integrate stereotyped combinations of 5+ input glomeruli. revealed 12/16 connections expected from EM data with a 10 synapse threshold. The top partner had >400 outputs onto the donor cells. 6/11

  2. 22. sij

    The HemiBrain dataset is preprinted! An impressive project, I did a bit of reconstruction for it in the LH. But intrepid fly network-anatomists pay attention to its brain region completion rates:

  3. 21. sij

    Our work here may be one of the last big beasts of the manual reconstruction era. See a spike in productivity when made his partial neuron auto-segmentation available to us? (essential plumbing from )

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  4. 20. sij
    Odgovor korisnicima i sljedećem broju korisnika:

    We see clear parallels in circuit logic across 4 different olfactory areas. But there are noticeable differences: the lateral horn has extensive modulation of both incoming axons and output neurons. This may allow state / memory to gate innate behavioural pathways. 11/12

  5. 20. sij
    Odgovor korisnicima i sljedećem broju korisnika:

    The other more unexpected class are 10 ‘centrifugal’ neurons. They collect their input from the mushroom body MBONs and project axons to the lateral horn. It seems most memory read-out neurons can strongly influence ‘innate’ processing in the lateral horn. 10/12

  6. 20. sij
    Odgovor korisnicima i sljedećem broju korisnika:

    Two other classes of neuron also give prominent input to the LH. The first are putative wind-sensitive PNs. Fascinatingly they get input from olfactory memory read-out neurons of the mushroom body (MBONs), a new motif integrating learned and innate information. 9/12

  7. 20. sij
    Odgovor korisnicima i sljedećem broju korisnika:

    Only 1/3 of input onto lateral horn dendrites comes from incoming excitatory PNs – local interneurons provide a similar amount. The LH looks particularly integrative – elsewhere the main output neurons receive most of their input from the main input neurons. 8/12

  8. 20. sij
    Odgovor korisnicima i sljedećem broju korisnika:

    Odour channel inputs onto lateral horn (LH) neurons weren’t really known. We built 66 LH neurons and found that all neurons (even local interneurons) could be split into axon and dendrite (using ’s algorithm). Dendrites are almost always closer to the soma. 7/12

  9. 17. sij

    A bit belated - but my supervisor ( , ) gave a brilliant public lecture yesterday to a ~300 strong audience, on receipt of his Francis Crick Medal from . The video is going to be useful for years: .... next stop, FRS?

  10. 12. stu 2019.

    We want the community to improve the natverse! Just merged a PR from to read Neuprint ROIs. Future: reading from more online databases, analysis of neurons as 3d meshes and support for other languages, e.g. to play nicely with ‘s MATLAB TREES toolbox 10/10

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  11. 12. stu 2019.

    This is super powerful because it allows us to repeatably find the same morphological cell types between different datasets, e.g. linking neurons sparse genetic lines (confocal microscopy) to manual/auto segmentations (flood-filling EM data, and ) 9/10

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  12. 12. stu 2019.

    This works if you have registered data. An important outcome is that and registered hundreds of fly brain images to standard template brains, made available at . Here’s ‘s clones (IS2) matched with Chiang lab neurons (FCWB) 8/10

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  13. 12. stu 2019.

    developed ‘bridging registrations’ to unify the standard templates in fly neuroscience, so you don’t need to waste time and energy re-registering different datasets. There is also support for the latest templates from and 7/10

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  14. 12. stu 2019.

    One of the things that set the natverse apart is that it geared to consider neurons registered to whole-brain / sub-region standard templates. This is critical in large-scale mapping projects inc connectomics. You must move data between them to compare datasets 6/10

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  15. 12. stu 2019.

    You can look at a lot, including NeuroMorpho, (), FlyCircuit (Ann-Shyn Chiang), MouseLight (), CATMAID (, , ), DVID, NeuPrint (, W. Katz) and NeuroGlancer () 5/10

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  16. 12. stu 2019.

    Since ~2003, has been developing tools in to work with neuron data (meanwhile, I was in primary school). Today, thanks to and you can also interoperate with python 4/10

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  17. 12. stu 2019.

    You should also be able to install the natverse with one line of code from R () and we have a responsive help group: 3/10

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  18. 12. stu 2019.

    The natverse allows you to easily plot neurons and neuroanatomical volumes, measure features and implement interesting algorithms, e.g. flow centrality and NBLAST . We give lots of examples: 2/10

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  19. 12. stu 2019.

    🎶welcome to the - we’ve got tools for brains!🎶Open software to analyse neurons, connections, brains Others are using it, why should you? : lab 1/10

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  20. 2. stu 2019.

    Bailey’s Drosophila-vial lab ‘shots’ at ’s lab party.

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