500 is big enough that, over time, genetic diseases can be bred out of the population w/o sacrificing diversity
I mean, this gets squicky but viability partly is based on assumption that you need X% of healthy offspring per generation to survive
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Even in animals with big litters you can't waste that much energy on nonviable babies (and humans have small litters)
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But in lab conditions w unlimited food we can get viable populations out of hyper-inbred animals
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