I will say he has a point about this, I've never used 23andMe and never intend to and find everyone who has done it to be extremely irritatinghttps://twitter.com/sullydish/status/1384164919428358145 …
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And his doctor just bluntly tells him "It's because you're highly inbred" (his ancestors are from a very small pool so all the markers in the reference data show up) As is true of many "historic" populations of insular Irish-American Catholic immigrants
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There's a whole range of factors that imposed bottlenecks on the populations of Irish people in Ireland and in the USA.
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