The idea that biology can make a mistake is a large part of the problem. There are no errors in biology. It does what it does. "Error" implies there is a correct way for the laws of nature to play out and that sometimes something else happens that is against the laws of nature.
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For some reason I read "factors" as "errors" but I think what I said still applies, given the usual discussion surrounding gametes and their purpose.
End of conversation
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