Please note that the "hygiene hypothesis" (our immune systems in the modern day are understimulated because our environments are too clean and uniform and that's why we have chronic health problems) is controversial, not settled science, and doesn't mean not to wash your hands
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Replying to @arthur_affect
People for get that the hygiene hypothesis really only concerns autoimmune disorders and the part of our immune system that evolved to fight *parasites*. Not viruses.
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Replying to @TheRedRaptor
Yeah the biggest difference between you and your ancestors here is you don't have worms in your gut (and the cells whose job it is to emit toxins and keep the worm population down are the same ones that cause allergic response)
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Replying to @arthur_affect @TheRedRaptor
Cells at Work funnily enough kind of gestures at this, with Eosinophil being the quiet bullied girl all the other immune cells make fun of until one day the human eats some bad sushi and she gets her moment to shine
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(The thing being, sushi worms - Anasakis simplex - aren't a true human parasite, they can't live in the human stomach and quickly die All the nasty symptoms are caused by the allergic immune response But of course the cells don't know the difference)
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