The funny thing is Cells at Work is so tightly focused on the drama of life as an immune system cell in the bloodstream "They should do HIV/AIDS next" makes perfect sense even though it sounds like an edgelord joke
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It would be a role reversal, the macho elitist bullying Killer Ts suddenly becoming the victims, and the other cells suddenly realizing how much they depended on them as all the little scrub germs start walking around like they own the place in their absence
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The problem, of course, is that there is no cure for full blown AIDS so the arc couldn't have an ending
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The same is true for the other idea for a big arc, lupus (the T-cells become corrupt and start irrationally targeting their own citizens and begin a civil war)
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Replying to @arthur_affect
Obviously the final episode should be death itself. Blood's stopped circulating, the bacteria will eventually eat everything, but the T-cells are still alive for a few hours.
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Replying to @GGarethwilson
Honestly the last episode of S1 of the anime was pretty dramatic The human has sustained a major injury and gone into hemorrhagic shock, they're bleeding out through their wound (so the roads populated by blood cells are nearly empty and the city looks post-apocalyptic)
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And our protagonist Red Blood Cell says even if all hope is lost and the city dies today she will continue transporting oxygen until the very moment the heart and lungs stop working because that is the purpose she was created for Every second of life is precious
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Replying to @arthur_affect @GGarethwilson
(I guess from their perspective every second is like several hours but still)
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