The funny thing is Cells at Work is so tightly focused on the drama of life as an immune system cell in the bloodstream "They should do HIV/AIDS next" makes perfect sense even though it sounds like an edgelord joke
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The anime characterization of blood parts suggests certain other plot arcs Like the Platelets being these construction crews of impossibly adorable tiny children means you've *got* to do an episode about reactive thrombocytosis
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A bunch of germs succeed in laying waste to a large part of the city and the Platelets get *so worried and upset* they start flooding the streets in an adorable rampage to go rebuild it, creating traffic jams for all the other cells
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The main characters are like if someone doesn't calm the Platelets down they'll start to trip and fall and drop their building supplies (clotting factors) all over the place and that will lead to road closures
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I just had something around 20 tests done as a diffdiag for Fibromyalgia, and, damn near 2/3rds were for lupus, it was astounding to hear my doctor read out oneafter another "Lupus variant" "cousin of lupus" "this one'sliver function." "lupus again" was, and is, an absurd disease
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The House MD joke about someone always suggesting the mystery illness is lupus makes *sense* - your body beginning to attack itself can cause pretty much any symptom you can think of - but the way it became a running gag was kind of shitty to real people with lupus
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Obviously the final episode should be death itself. Blood's stopped circulating, the bacteria will eventually eat everything, but the T-cells are still alive for a few hours.
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Honestly the last episode of S1 of the anime was pretty dramatic The human has sustained a major injury and gone into hemorrhagic shock, they're bleeding out through their wound (so the roads populated by blood cells are nearly empty and the city looks post-apocalyptic)
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