The funny thing is Cells at Work is so tightly focused on the drama of life as an immune system cell in the bloodstream "They should do HIV/AIDS next" makes perfect sense even though it sounds like an edgelord joke
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The problem, of course, is that there is no cure for full blown AIDS so the arc couldn't have an ending
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The same is true for the other idea for a big arc, lupus (the T-cells become corrupt and start irrationally targeting their own citizens and begin a civil war)
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The anime characterization of blood parts suggests certain other plot arcs Like the Platelets being these construction crews of impossibly adorable tiny children means you've *got* to do an episode about reactive thrombocytosis
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A bunch of germs succeed in laying waste to a large part of the city and the Platelets get *so worried and upset* they start flooding the streets in an adorable rampage to go rebuild it, creating traffic jams for all the other cells
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The main characters are like if someone doesn't calm the Platelets down they'll start to trip and fall and drop their building supplies (clotting factors) all over the place and that will lead to road closures
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