Anna Brandberg

No.

There have been a number of films taegetted at to the female audience that didn't completely bomb out. As such, your statement is misleading. Comic fandom entails both male and female and everything between. Historically, the comic fanbase was primarily female.

So many movies featuring only men, and targeted exclusively towards men, have done fine. Similarly, movies targeted exclusively for women, have also done fine. I think you'll find this movie, too, will do just fine.

I didn't see Alita or Tomb raider in cinemas for one very specific reason, and Anna, being a compadre in creative media, will very likely agree. Anime/manga and games ALMOST NEVER translate well into other media formats.