Virologist. PI @VIDOInterVac. Adj Prof @USask BMI. Aff @georgetown_ghss. Pillar 2 @covarr_net. Jeopardy! loser. 
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. Rep @anniescranton. she/her
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This is a good thread and I agree with Dr. Gottlieb's considerate view, with the exception of this. We know that when growing SARS-CoV-2 in cell culture, it rapidly becomes cell culture-adapted & loses some features (such as the FCS) important for human infection & disease.
There is quite a lot of data on SARS-CoV-2 and how it behaves in the lab vs. in people. If cell culture results in the loss of key virulence factors, the idea that well-intentioned research went awry becomes less plausible from a virology perspective.
The problem is that the first question, is it possible to escape from a lab, is one thing. But the question of pre-adaptation is a question of molecular virology and i don’t understand how an intelligent non-virologist even forms an opinion on it.
Very interesting.
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agree:
"As far as the lab leak theory, there's two narratives here, and one is interfering with the other." -
