Skip to content
  • Home Home Home, current page.
  • Moments Moments Moments, current page.

Saved searches

  • Remove
  • In this conversation
    Verified accountProtected Tweets @
Suggested users
  • Verified accountProtected Tweets @
  • Verified accountProtected Tweets @
  • Language: English
    • Bahasa Indonesia
    • Bahasa Melayu
    • Català
    • Čeština
    • Dansk
    • Deutsch
    • English UK
    • Español
    • Filipino
    • Français
    • Hrvatski
    • Italiano
    • Magyar
    • Nederlands
    • Norsk
    • Polski
    • Português
    • Română
    • Slovenčina
    • Suomi
    • Svenska
    • Tiếng Việt
    • Türkçe
    • Ελληνικά
    • Български език
    • Русский
    • Српски
    • Українська мова
    • עִבְרִית
    • العربية
    • فارسی
    • मराठी
    • हिन्दी
    • বাংলা
    • ગુજરાતી
    • தமிழ்
    • ಕನ್ನಡ
    • ภาษาไทย
    • 한국어
    • 日本語
    • 简体中文
    • 繁體中文
  • Have an account? Log in
    Have an account?
    · Forgot password?

    New to Twitter?
    Sign up
angie_rasmussen's profile
Dr. Angela Rasmussen
Dr. Angela Rasmussen
Dr. Angela Rasmussen
Verified account
@angie_rasmussen

Tweets

Dr. Angela RasmussenVerified account

@angie_rasmussen

Virologist. PI @VIDOInterVac. Adj Prof @USask BMI. Aff @georgetown_ghss. Pillar 2 @covarr_net. Jeopardy! loser. 🇺🇸in 🇨🇦. Rep @anniescranton. she/her

Saskatoon, Saskatchewan
angelarasmussen.org
Joined October 2011

Tweets

  • © 2022 Twitter
  • About
  • Help Center
  • Terms
  • Privacy policy
  • Cookies
  • Ads info
Dismiss
Previous
Next

Go to a person's profile

Saved searches

  • Remove
  • In this conversation
    Verified accountProtected Tweets @
Suggested users
  • Verified accountProtected Tweets @
  • Verified accountProtected Tweets @

Promote this Tweet

Block

  • Tweet with a location

    You can add location information to your Tweets, such as your city or precise location, from the web and via third-party applications. You always have the option to delete your Tweet location history. Learn more

    Your lists

    Create a new list


    Under 100 characters, optional

    Privacy

    Copy link to Tweet

    Embed this Tweet

    Embed this Video

    Add this Tweet to your website by copying the code below. Learn more

    Add this video to your website by copying the code below. Learn more

    Hmm, there was a problem reaching the server.

    By embedding Twitter content in your website or app, you are agreeing to the Twitter Developer Agreement and Developer Policy.

    Preview

    Why you're seeing this ad

    Log in to Twitter

    · Forgot password?
    Don't have an account? Sign up »

    Sign up for Twitter

    Not on Twitter? Sign up, tune into the things you care about, and get updates as they happen.

    Sign up
    Have an account? Log in »

    Two-way (sending and receiving) short codes:

    Country Code For customers of
    United States 40404 (any)
    Canada 21212 (any)
    United Kingdom 86444 Vodafone, Orange, 3, O2
    Brazil 40404 Nextel, TIM
    Haiti 40404 Digicel, Voila
    Ireland 51210 Vodafone, O2
    India 53000 Bharti Airtel, Videocon, Reliance
    Indonesia 89887 AXIS, 3, Telkomsel, Indosat, XL Axiata
    Italy 4880804 Wind
    3424486444 Vodafone
    » See SMS short codes for other countries

    Confirmation

     

    Welcome home!

    This timeline is where you’ll spend most of your time, getting instant updates about what matters to you.

    Tweets not working for you?

    Hover over the profile pic and click the Following button to unfollow any account.

    Say a lot with a little

    When you see a Tweet you love, tap the heart — it lets the person who wrote it know you shared the love.

    Spread the word

    The fastest way to share someone else’s Tweet with your followers is with a Retweet. Tap the icon to send it instantly.

    Join the conversation

    Add your thoughts about any Tweet with a Reply. Find a topic you’re passionate about, and jump right in.

    Learn the latest

    Get instant insight into what people are talking about now.

    Get more of what you love

    Follow more accounts to get instant updates about topics you care about.

    Find what's happening

    See the latest conversations about any topic instantly.

    Never miss a Moment

    Catch up instantly on the best stories happening as they unfold.

    Dr. Angela Rasmussen‏Verified account @angie_rasmussen 5 May 2020

    This type of reporting on #SARSCoV2 #COVID19 #coronavirus makes my blood boil. There is no evidence that the dominant strain is such because it is "more contagious"https://www.latimes.com/california/story/2020-05-05/mutant-coronavirus-has-emerged-more-contagious-than-original?_amp=true&__twitter_impression=true …

    9:58 AM - 5 May 2020
    • 1,322 Retweets
    • 3,269 Likes
    • Celtic Warrior Woman 🏴󠁧󠁢󠁳󠁣󠁴󠁿🇺🇲🍁🍂🍁☃️🌲⛄ Ryan Ryo Komorizono MPuopolo Scott Myers Proud Texas Democrat! Hsquared Studio. Bro La Mbezi chanze
    163 replies 1,322 retweets 3,269 likes
      1. New conversation
      2. Dr. Angela Rasmussen‏Verified account @angie_rasmussen 5 May 2020

        It's based on this pre-print, which is strictly a computational analysis of virus sequences. They found a mutation that became dominant over time but didn't do anything to show its functional significance in transmission. https://www.biorxiv.org/content/10.1101/2020.04.29.069054v1 …

        8 replies 131 retweets 512 likes
        Show this thread
      3. Dr. Angela Rasmussen‏Verified account @angie_rasmussen 5 May 2020

        The old adage that correlation does not equal causation applies here. If you are looking at sequence data alone, you can't show effect that this single mutation, spike D614G has on transmission. This means that a mutation at position 614 in spike changed aspartic acid to glycine.

        9 replies 84 retweets 453 likes
        Show this thread
      4. Dr. Angela Rasmussen‏Verified account @angie_rasmussen 5 May 2020

        This happened during the West African Ebola epidemic too. Two groups tested a mutation in Ebola GP (analogous to spike--it's the envelope glycoprotein of Ebola that binds the receptor), called A82V, meaning an alanine was replaced by valine at amino acid #82 in GP.

        1 reply 46 retweets 242 likes
        Show this thread
      5. Dr. Angela Rasmussen‏Verified account @angie_rasmussen 5 May 2020

        Importantly, these studies actually did experiments to show that A82V increased infectivity (the ability to infect cells) in surrogate systems (not actual Ebola virus). Claims about A82V's function in infection and pathogenesis were not made based solely on sequence data.

        1 reply 40 retweets 210 likes
        Show this thread
      6. Dr. Angela Rasmussen‏Verified account @angie_rasmussen 5 May 2020

        This made the news in a big way. The scale and scope of the West African Ebola epidemic was attributed to A82V making the virus not only more transmissible, but also more pathogenic, or "nastier" as this article states.https://www.newscientist.com/article/2111311-ebola-rapidly-evolves-to-be-more-transmissible-and-deadlier/ …

        1 reply 39 retweets 201 likes
        Show this thread
      7. Dr. Angela Rasmussen‏Verified account @angie_rasmussen 5 May 2020

        In cell culture, the A82V mutation did appear to improve viral fitness (the overall ability of the virus to infect cells and replicate), which may explain why this emerged early in the epidemic and there was selection pressure to maintain the A82V change. https://jvi.asm.org/content/91/2/e01913-16 …

        2 replies 37 retweets 173 likes
        Show this thread
      8. Dr. Angela Rasmussen‏Verified account @angie_rasmussen 5 May 2020

        However, when the mutation was tested in animals, it had no effect on pathogenesis or viral shedding. Thus it's a cautionary tale on making broad conclusions about pathogenicity and transmissibility based on in vitro studies w/ surrogate viruses. https://linkinghub.elsevier.com/retrieve/pii/S2211-1247(18)30569-2 …

        5 replies 53 retweets 284 likes
        Show this thread
      9. Dr. Angela Rasmussen‏Verified account @angie_rasmussen 5 May 2020

        And for Ebola GP A82V, these conclusions were based on a number of rigorous, well-controlled experiments conducted by teams of respected virologists. Spike D614G from #SARSCoV2 has not ever been tested in a single experiment. This is based solely on computational analysis.

        3 replies 40 retweets 216 likes
        Show this thread
      10. Dr. Angela Rasmussen‏Verified account @angie_rasmussen 5 May 2020

        The title of the preprint is very misleading. "Spike mutation pipeline reveals the emergence of a more transmissible form of SARS-CoV-2"...NO it does not. It reveals the emergence of a substitution of aspartic acid for glycine at position 614.

        6 replies 107 retweets 403 likes
        Show this thread
      11. Dr. Angela Rasmussen‏Verified account @angie_rasmussen 5 May 2020

        Spike D614G may well have functional importance. It may even increase transmissibility. But we won't know until this is tested experimentally. There's no basis for the breathless OMG #SARSCoV2 HAS MUTATED TO BE MORE TRANSMISSIBLE WE'RE ALL GONNA DIE tone in the LA Times piece.

        12 replies 135 retweets 464 likes
        Show this thread
      12. Dr. Angela Rasmussen‏Verified account @angie_rasmussen 5 May 2020

        Then there's this line: "The report’s authors said they felt an “urgent need for an early warning” so that vaccines and drugs under development around the world will be effective against the mutated strain." Early warning about...what, exactly? Any #SARSCoV2 transmission is bad

        3 replies 41 retweets 226 likes
        Show this thread
      13. Dr. Angela Rasmussen‏Verified account @angie_rasmussen 5 May 2020

        If you don't know what a single amino acid change even does, why is there an "urgent need for an early warning"? Warning about what? Are there any vaccines or drugs specifically targeting position 614 in spike? We don't even know if this has any kind of biological effect.

        8 replies 42 retweets 265 likes
        Show this thread
      14. Dr. Angela Rasmussen‏Verified account @angie_rasmussen 5 May 2020

        While it's good to know that this mutation appears to be under positive evolutionary selection, and we should study it to see if it is important for viral fitness or infectivity, it's way too premature to be sounding an "early warning" alarm that OmG tHe ViRuS iS mUtAtInG!!!

        11 replies 63 retweets 373 likes
        Show this thread
      15. Dr. Angela Rasmussen‏Verified account @angie_rasmussen 5 May 2020

        These conclusions about increased transmissibility based on correlation analyses are an overreach. We don't know if the virus is "more transmissible." Experimental evidence or it didn't happen.

        38 replies 68 retweets 401 likes
        Show this thread
      16. End of conversation

    Loading seems to be taking a while.

    Twitter may be over capacity or experiencing a momentary hiccup. Try again or visit Twitter Status for more information.

      Promoted Tweet

      false

      • © 2022 Twitter
      • About
      • Help Center
      • Terms
      • Privacy policy
      • Cookies
      • Ads info