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andrew_croxford's profile
Andrew L. Croxford
Andrew L. Croxford
Andrew L. Croxford
@andrew_croxford

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Andrew L. Croxford

@andrew_croxford

Immunologist for about 20 years. Just opinions of mine, not representative of any organisation or affiliation. Not medical advice, obviously.

scholar.google.com/citations?user…
Joined November 2020

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    1. Andrew L. Croxford‏ @andrew_croxford 29 Dec 2021

      According to Extended Data Table 2, Patient 3, 7, 10, 12 & 28 did *not* receive GC. Where was viral RNA found in these autopsies? Patient 3: Barely detectable anywhere. Patient 7: Immunosuppression post kidney transplant - similar issue for GC/steroids. Viral RNA high!pic.twitter.com/9Zlw5MpWQx

      2 replies 20 retweets 209 likes
      Show this thread
    2. Andrew L. Croxford‏ @andrew_croxford 29 Dec 2021

      Continued: Patient 10: Low levels in lung and gut (expected), a drop in mediastinal LN Patient 12: Low levels in lung, gut (expected) Patient 28: Readily detectable in lung/heart/kidney - obese/hypertension, short illness

      2 replies 15 retweets 160 likes
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    3. Andrew L. Croxford‏ @andrew_croxford 29 Dec 2021

      How do systemic GC influence viral dissemination? Even if low dose GC can help certain patients to get on top of an infection, what do we learn about viral persistence in a study in which 90% of participants received GC? For me, this is tough to interpret.

      2 replies 15 retweets 174 likes
      Show this thread
    4. Andrew L. Croxford‏ @andrew_croxford 29 Dec 2021

      Andrew L. Croxford Retweeted Enola

      Yes, what about LC? A good question also posed in the study. Certainly possible post-hospitalisation for those needing GC, by the looks of this. But it’s not clear that this will often happen in vaccinated, or otherwise healthy people.https://twitter.com/SuffragetteLane/status/1473798491532980226?s=20 …

      Andrew L. Croxford added,

      Enola @SuffragetteLane
      Replying to @DrZoeHyde
      Does this help explain long COVID?
      3 replies 15 retweets 163 likes
      Show this thread
    5. Andrew L. Croxford‏ @andrew_croxford 29 Dec 2021

      And what of those mentioned in the abstract who, even with mild COVID, showed dissemination? Only *two* people, where the asymptomatic case is a six year old with Dravet syndrome who tragically succumbed to cerebral ischema, likely linked to this comorbidity according to authors.pic.twitter.com/ekJHaguWLG

      4 replies 16 retweets 185 likes
      Show this thread
    6. Andrew L. Croxford‏ @andrew_croxford 29 Dec 2021

      So, I ask you… is this an ideal cohort of people in Dec 2021 to assess viral dissemination as a mechanism for Long COVID? 🤔 Unvaccinated, nearly all receiving GC, 75% with at least two serious risk factors? 🤔 It's tricky to say and should probably be presented as such!

      5 replies 29 retweets 433 likes
      Show this thread
    7. Andrew L. Croxford‏ @andrew_croxford 29 Dec 2021

      More generally: * If there is no control group, say so! * If your case study isn’t representative for a plethora of reasons, say so! * If cohorts aren’t well matched, say so! * Make clear the limitations and why they are important for interpretation!

      3 replies 47 retweets 622 likes
      Show this thread
    8. Andrew L. Croxford‏ @andrew_croxford 29 Dec 2021

      I am no fan of allowing omicron to spread rampantly in a immunologically naive demographic. If you wanna be ultra-cautious, fine. But to present this as ‘the norm’ to advocate for restrictions should be avoided. Do look at the replies. Most blindly trust the headline.

      8 replies 29 retweets 541 likes
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    9. Andrew L. Croxford‏ @andrew_croxford 29 Dec 2021

      This is what separates “SciComm” from activism & campaigning. I’m not sure everyone can tell the difference. With a medium/largeish-sized account myself, I know how these tweets can run. This may have flashed over 1M screens in less than 24h.

      8 replies 33 retweets 518 likes
      Show this thread
    10. Andrew L. Croxford‏ @andrew_croxford 29 Dec 2021

      The media will of course pick it up, and we know that most people don’t get past the headline. That’s not the media’s fault, or even the person who posts the paper like Dr. Hyde but it's a reality & if they do seek out the data, most can’t dissect it.https://www.gizmodo.com.au/2021/12/the-coronavirus-can-persist-for-months-in-brain-heart-and-intestines-major-study-finds/ …

      7 replies 14 retweets 309 likes
      Show this thread
      Andrew L. Croxford‏ @andrew_croxford 29 Dec 2021

      So pretty please, let’s make efforts to empower people with necessary information. Presenting specialist medical literature without limitations that confuses/frightens people, even if unintended, isn't great. If this is in your repertoire, try to cut it out in 2022!pic.twitter.com/7qtv3JWA4p

      7:13 AM - 29 Dec 2021
      • 61 Retweets
      • 760 Likes
      • Margaret LINDSAY Holton A.Genova MD Chad Wilson Margaret Young Caitlin Sainio hechizante777 Well Boosted Natalie BetoForGovernor
      48 replies 61 retweets 760 likes
        1. Cautious Stoat‏ @cautiousstoat 29 Dec 2021
          Replying to @andrew_croxford

          Brilliant thread Andrew

          0 replies 0 retweets 5 likes
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        1. Sic Transit‏ @ozymandite 29 Dec 2021
          Replying to @andrew_croxford

          Maybe you haven’t seen much of Zoe Hyde’s tweeting but I struggle to believe that she didn’t intend to alarm.

          0 replies 0 retweets 1 like
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        1. Dino Mitt‏ @FaktaShake 29 Dec 2021
          Replying to @andrew_croxford

          You’re being way too nice.

          0 replies 0 retweets 1 like
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        2. Adam W Gaffney‏Verified account @awgaffney 29 Dec 2021
          Replying to @andrew_croxford

          I agree with need for caution/care. Another important issue is the still unclear clinical implications of the identification of extra-pulmonary virus. As the authors note, there was not significant inflammatory change or direct viral cytopathology outside the lungs. Also,

          1 reply 1 retweet 7 likes
        3. Adam W Gaffney‏Verified account @awgaffney 29 Dec 2021
          Replying to @awgaffney @andrew_croxford

          ...another autopsy series w/ similar findings (i.e. widespread viral spread) concluded that "none of the [histolopathological] findings was specific for direct viral injury...", and asserted that clinical relevance of the PCR findings was uncertain.https://ccforum.biomedcentral.com/articles/10.1186/s13054-020-03218-5 …

          1 reply 1 retweet 6 likes
        4. Show replies
        1. Dr Ed‏ @notdred 29 Dec 2021
          Replying to @andrew_croxford

          Fantastic thread Andrew! 👏🏽

          1 reply 0 retweets 8 likes
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        1. GirlWhoWaited01‏ @ElleWoods1981 29 Dec 2021
          Replying to @andrew_croxford

          Agree 100%. I’ve seen so many non-peer-reviewed studies with tiny sample sizes and huge error bars reported on without the necessary context as if they’re gospel truth and it’s absolutely maddening.

          0 replies 0 retweets 2 likes
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        1. Lucy Garrett QC‏ @lucifee 29 Dec 2021
          Replying to @andrew_croxford

          It’s not just your photoshop that’s great.

          0 replies 0 retweets 1 like
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        1. Kate Paul Dillon.‏ @KatePaulDillon 29 Dec 2021
          Replying to @andrew_croxford

          This thread was sexy. Thank you.

          0 replies 0 retweets 1 like
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        1. Ralph Erskine‏ @deserter1900 29 Dec 2021
          Replying to @andrew_croxford

          👏thank you Mr Croxford. Headlines and sloppy conclusions are being misused by some to push an agenda without understanding. It is very very frustrating to see research misused in this way, and it gets in the way of progress. Great thread.

          0 replies 0 retweets 2 likes
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