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Can we understand dynamics of immune memory as Bayesian inference of changing pathogen frequencies? Our paper now out @PNASNewshttps://doi.org/10.1073/pnas.1812810116 …
This paper has been a long time in the making so it's great to finally see it out! :D It took us several years to find a tractable setup in which to mathematically formalize these ideas and to then synthesize what we've learned about immune dynamics.
It's a dense read and there's a long SI. We tried to provide the broad conceptual ideas in an accessible manner without burying the interesting mathematical results on how to do exact stochastic filtering for drift-diffusion environmental dynamics.
Can you post a synopsis accessible to us mere mortals?
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