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usually not viable - most useful problems are not good at being PoW, and most good PoWs are not very useful (eg proofs must be small and quick to verify, as every node must store and validate a full chain of them)

9:56 PM · Jun 5, 2021Twitter Web App

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and

also, algorithmic improvements that help the real-world case either break your PoW, or are not incentivized by it, and once you have such an improvement, the usefulness of your chain diminishes for people solving real-world problems