an interesting paradox: many highly serotonin-affecting drugs are cardiotoxic in chronic use.
but LSD is oddly safe despite affecting the same receptors! interesting analysis on page 3 here sci-hub.tw/10.1016/j.pnpb
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i think the theory (if i'm reading it right) is that LSD is a very powerful and highly selective *partial agonist*, while many other compounds (especially designer drugs) tend to be full agonists, which are responsible for the cardiotoxicity
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I recently learned about why hearts respond to serotonin and basically it's a heinous hack that somehow made it into production (src: endofshiftreport.com/2015/12/a-youn)
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// HACK: during switchover to in-air-operation, a number of hormone levels change permanently. This is a robust enough signal that we didn't install an extra pathway for that, and it only happens once anyway,