In brief: Maybe we can't all be happy and have meaningful lives all the time now. But maybe our descendants will thanks to DNA technology.
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Arguably meaning in the brain is implemented with valence gradients. Anti-wireheading mechanisms prevent us from "winning".
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But in principle we could reverse-engineer what makes meaning pleasant (e.g. https://qualiacomputing.com/2016/08/20/wireheading_done_right/ … and http://mdma.net ).
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So "winning" (i.e. having a near-perpetual hyper-valuable super-meaningful life) may just be a matter of figuring out what bliss is at the..
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..biomolecular, functional, quantum or chemical level (whatever may be the level of resolution that matters).
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