Serotonergic psychedelics also work. It seems that it’s specifically 5HT2c receptors that are linked to stopping opioid withdrawal effects.
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Based on Tomas Ray work on receptor affinity, that would perhaps make DOI the most promising anti-tolerance psychedelic. What do you think? It also has relatively low 5HT2b affinity, which I like as that's the one receptor associated with cardiotoxicity.https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009019 …
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