fun fact: tolerance to a drug's effects may grow at different rates depending on the effect that is, if a single drug has effect A and effect B, you can grow tolerant to A faster than B. this can be real fuckin' bad.pic.twitter.com/I9oAshtFyv
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Another super important thread to pull is the question of whether there are anti-tolerance agents. That is, agents that reduce, prevent, or even reverse tolerance if co-administered with the drug in question. See:https://qualiacomputing.com/2018/11/07/anti-tolerance-drugs/ …
oh they definitely exist, e.g. ketamine (and NMDA antagonists in general) are known to work for opioids
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