Conversation

1) Terwilliger et al. explored how well AF models fit into experimentally derived electron density maps. So far, the accuracy of AF models has mainly been assessed by how well predictions match protein structures but not the actual electron density.
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2) Karelina et al. examined how useful AF2 models are for predicting protein-drug interactions. Molecular docking analyzes the interactions between ligands and protein structures, identifying potential drug candidates.
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I think the studies above are good reminders that predicted models are great for hypothesis creation but that it's still a very long way until we can use them to develop new drugs. Experimental is still👑
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