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Compressed everything I learned about how life sciences work in the last year (and 100+ interviews) into 6000 words:https://guzey.com/how-life-sciences-actually-work/ …
just got a fascinating email in response to my essay: "It is very easy to get funding for students and post-docs, but virtually impossible to get funding for a full-time technician or researcher that can oversee or assist or manage research for multiple projects."pic.twitter.com/ccbQfYh7ud
the post took a quote from @cshalizi out of context to make roughly the opposite point from the one he was making http://bactra.org/weblog/practical-peer-review.html …
thanks so much! I read the @cshalizi's post except for the last paragraph, having forgotten that he turns around and says that peer review is good. I still disagree but I removed his quote from the post because this is indeed misrepresentation.
(would you mind acknowledging you somewhere in the appendix -- will add a section on edits/mistakes?)
Go ahead, thanks for fixing
took thousands of people to read the essay before someone noticed this smh.....
this can be interpreted as an argument against peer review! :) I had >10 people read the draft before publication because prior experience shows that 2-3 careful readers almost never catch even the majority of problems
however 2-3 careful but critical readers are enough to shoot down a worthy but novel and difficult to understand idea...
Interesting. I’m a life science investor. I agree pace of innovation in lifesci is not slowing (it varies in domains tho). Re: Replication, have you seen the work suggesting experts in field tend to know which studies won’t replicate? Implying experts know what’s genuine.
this is not what that paper shows - I think authors overstate their results a bit! Experts are not at all good at predicting which research will replicate
on pic: out of 8 studies that had >80% prob of replication only 3 replicate!
@xoxo_meme_queen https://www.pnas.org/content/112/50/15343 …pic.twitter.com/rrK04xpNbK
What do you think of the idea that it’s partly a base rate fallacy effect ?https://academic.oup.com/bjps/advance-article-abstract/doi/10.1093/bjps/axy051/5071906 …
super interesting, thank you!
On big vs small - have you seen this paper suggesting big teams = incremental / development and small teams = transformational / disruptive (But probably rarer). So you need both types. https://arxiv.org/ftp/arxiv/papers/1709/1709.02445.pdf … and my mini take -https://www.thendobetter.com/investing/2019/2/24/small-teams-vs-large-teams-and-innovation-effects …
isn't this just correlation?
Unsure. (Most/many things are correlation). But it ties in with with what many people anecdotally think about large companies vs small companies and how teaming might work.
I do find the hypothesis plausible!.. but I doubt this paper is something I should use as evidence
do you find yourself more annoyed with conversations about life sciences now?
you can't believe how mad i am now at everyone
Really good synthesis of the state of life sciences (in the US), great job
thank you!
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