Started with continuous model, reduced it to a discrete model representing connection strengths/lengths in a matrix. Able to reproduce some disease patterns (But not ALS)pic.twitter.com/Na1BjNBlBm
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Interesting talk last night in Cambridge “Mathematics vs dementia” modelling how disease spreads through the brain following the connectome. http://talks.cam.ac.uk/talk/index/132205 …pic.twitter.com/hBxhRQsn2w
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This view was interesting. The two obvious regions are the left and right hemispheres - the sparse quarters show how little connection there is between them.pic.twitter.com/ZrSHhaW8Ry
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Two gaps at present: 1. Hard to use direction of connections in model because we don’t have the data for human brains 2. Model depends on parameters that they can’t relate to in vitro data. (If they use in vitro data, model would have you dead in weeks not decades)
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