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Prostaglandin Biosynthesis Reinforces Cellular Senescence Through a RAS/p53 Feedback Loop and Allows Detection of Senolysis
#preprint@BuckInstitute https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3528689 …pic.twitter.com/Nwn7Cl9vvV
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Prolonged disturbance of
#proteostasis induces cellular#senescence via temporal mitochondrial dysfunction and enhanced mitochondrial biogenesis in human fibroblasts https://www.biorxiv.org/content/10.1101/2020.01.22.916221v1 …pic.twitter.com/bKOXZrRpu2
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Online registration for the 2020 Metabolism,
#Aging, Pathogenesis and Stress in C. elegans#inworms https://uwmadison.eventsair.com/aging2020/reg/Site/Register?fbclid=IwAR0zZjEIIjcTB8MAr_LBNc2Wvea0_fnE1jN8wcuMCcDSeeKBtx52wCBKI4k …pic.twitter.com/Wou1O9mYG1
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"For example at 120 days, when approximately half of the animals had died, two-thirds of those remaining were still moving about on their plates without any prodding by the observer" https://science.sciencemag.org/content/302/5645/611 …pic.twitter.com/S9N3kIpXzE
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[Opportunity, please share!] This year, the
@MDIBL is organizing two Biology of Aging courses. The Impacts of Environmental Chemicals on Aging and Physiology: https://mdibl.org/course/bridging-disciplines-the-impacts-of-environmental-chemicals-on-aging-and-physiology/ … Comparative Aging and Regenerative Biology: https://mdibl.org/course/aging-regenerative-biology-2020/ …pic.twitter.com/l1vbARgj84
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Mitochondrial translation and dynamics synergistically extend lifespan in C. elegans through HLH-30
#preprint@rhhoutkooper https://www.biorxiv.org/content/10.1101/871079v1?rss=1 …pic.twitter.com/OEGc9EBQlJ
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The GID
#ubiquitin ligase complex is a regulator of#AMPK activity and C. elegans lifespan https://www.tandfonline.com/doi/full/10.1080/15548627.2019.1695399 …pic.twitter.com/ApTAtGwEOH
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Late life
#metformin treatment limits cell survival and shortens lifespan by triggering an aging-associated failure of energy metabolism https://www.biorxiv.org/content/10.1101/863357v1 …pic.twitter.com/UOyAy622bj
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Great lectures about aging and senescence by
@UriAlonWeizmann available at youtubehttps://www.youtube.com/watch?v=c3TGskV1CMg … -
Deficiency in the DNA repair protein ERCC1 triggers a link between
#senescence and apoptosis in human fibroblasts and mouse skin by Judith Campisi's group@BuckInstitute https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13072 …pic.twitter.com/gIXqdLTG6D
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An Inflammatory Clock Predicts Multi-morbidity, Immunosenescence and Cardiovascular Aging in Humans https://www.biorxiv.org/content/10.1101/840363v1 …pic.twitter.com/BmfbPlMo2h
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The ubiquitin-specific protease USP17 prevents cellular
#senescence by stabilizing the#histone methyltransferase SET8 - published at@jbiolchem http://www.jbc.org/content/early/2019/09/18/jbc.RA119.009006 …pic.twitter.com/XuDszHi6GK
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Also, co-submitted manuscript: "Erosion of the Epigenetic Landscape and Loss of Cellular Identity as a Cause of Aging in Mammals" https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3461780 …pic.twitter.com/NGMeSAgPBZ
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New
#preprint from@davidasinclair lab - DNA Break-Induced Epigenetic Drift as a Cause of Mammalian#Aging https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3466338 …pic.twitter.com/CiBwpsxSja
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Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain https://www.sciencedirect.com/science/article/pii/S096098221931019X …pic.twitter.com/8vxZJfHeB4
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Enhancing autophagy by redox regulation extends lifespan in Drosophila https://www.biorxiv.org/content/10.1101/790378v1 …pic.twitter.com/WjErqvnDXd
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Nice! A triple drug combination targeting components of the nutrient-sensing network maximizes longevity in flies at
@PNASNews https://www.pnas.org/content/early/2019/09/26/1913212116 …pic.twitter.com/GeIlnoy0jt
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Wow!
#Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults#workout#gym https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13039 …pic.twitter.com/m2z53oMRLA
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Gray whale transcriptome reveals longevity adaptations associated with DNA repair,
#autophagy and#ubiquitination https://www.biorxiv.org/content/10.1101/754218v1 …pic.twitter.com/kno1O9De5I
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