Sameer Aryal

@_sameeraryal

Graduate student in Eric Klann's group at . Neuroscience. Genomics. Bioinformatics. Formerly ,

New York, NY
Vrijeme pridruživanja: travanj 2013.

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  1. proslijedio/la je Tweet
    prije 14 sati

    ZipSeq from the Krummel lab ( ) prints spatially-patterned barcodes onto live cells within intact tissues. After dissociation and scRNA-seq, cells can be mapped to their original location!

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  2. 9. sij

    Interesting and very useful thread on multicistronic vector design.

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  3. proslijedio/la je Tweet
    9. pro 2019.

    Exciting! Our new manuscript on "The DNA of thing" with my colleague Robert Grass and his team at ! What's all about 🤔? A thread! 👇👇👇

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  4. proslijedio/la je Tweet
    3. pro 2019.

    Today I received the best email. A biology student wrote a review on Arc for their undergrad neuro class and she shared it with me. Blown away how good it is...love getting unsolicited messages like this!

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  5. proslijedio/la je Tweet
    18. stu 2019.

    If we could read out DNA barcodes in situ, we could “see” the history of individual cells directly in tissues. Here we show good old T7 polym transcribes barcodes in fixed cells, without in vivo expression, providing unexpected capabilities. 1/

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  6. proslijedio/la je Tweet
    15. lis 2019.

    Feel like we’re seeing the future of understanding complex disease genetics demo’d in schizophrenia by : allelic series that let us peel apart the biological mechanisms.

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  7. proslijedio/la je Tweet

    1) Had some students over tonight for dinner, and *they* started talking about the value of a liberal arts education. We covered all the various arguments, and then I confessed to them what for me is the most profound reason to pursue a liberal arts education:

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  8. proslijedio/la je Tweet
    26. ruj 2019.

    5 years, 9 genes, 1 goal: to design reporter genes for ultrasound. Mammalian Acoustic Reporter Genes make visible the location and function of human cells deep inside the body. Thanks to and an amazing team on this project.

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  9. proslijedio/la je Tweet
    25. ruj 2019.

    They may not be grounds for impeachment, but we have some cool results to share, in work by Heath Johnson, Stas Shvartsman and myself: "Optogenetic rescue of a developmental patterning mutant", posted to bioRxiv in the last day or so!

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  10. proslijedio/la je Tweet
    23. ruj 2019.

    You share at least 1 ancestor in the last 5k years with everyone alive today. Everyone from 15k years ago either has no descendants alive today, or is an ancestor to everyone alive today. We're all one big, rather closely related family.

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  11. 11. ruj 2019.

    A really elegant study that shines light on why majority of clinical trials of cancer drugs fail. Emphasizes the need for rigorous genetic verification of mechanism of action.

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  12. proslijedio/la je Tweet
    12. kol 2019.

    The three technologies bioinformaticians need to be using right now

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  13. proslijedio/la je Tweet
    1. kol 2019.

    Exciting to see and adopting . Congratulations to for publishing the first paper using . Thanks to for writing an excellent overview of estimation and effect sizes.

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  14. 27. srp 2019.

    Work from our lab investigating how acute, reversible reduction of protein synthesis in genetically defined neurons affects fear memory consolidation. I really enjoyed seeing this project develop over the years. Congratulations !

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  15. proslijedio/la je Tweet
    24. srp 2019.

    This is the wonderful work of Fenna Krienen. Some real surprises with regards to interneurons in NHPs. Turns out hippocampal immigrants into the cortex and innovations in the striatum add to the repertoire. Take a look!

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  16. proslijedio/la je Tweet
    16. srp 2019.

    A very cool new tool out in ⁦⁩ - cell-type specific inhibition of protein synthesis!

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  17. proslijedio/la je Tweet
    13. srp 2019.

    Excited to share a preprint of our latest Riboglow work in collaboration with local RNA imaging experts!

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  18. proslijedio/la je Tweet
    7. srp 2019.
    Odgovor korisnicima

    Fwis I always liked Dienes’ example of comparinf P dead|shark bites your head off versus P shark bit your head off|dead, ie >100% vs 0.00000001% - we want to know one but us the other as evidence (but might not be what you are after)

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  19. proslijedio/la je Tweet
    19. lip 2019.

    Our latest work now out in ! "Moving Beyond P Values: data analysis with estimation graphics". We show how estimation plots can improve statistical reasoning with elegant and informative estimation plots. 1/3

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  20. proslijedio/la je Tweet
    19. lip 2019.

    We're out in ! The paper "Moving beyond P values: data analysis with estimation graphics" details the motivation and design behind estimation graphics. Feel free to cite this paper when using estimation plots!

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