Book posting from The Neuropharmacological Basis of Rewardpic.twitter.com/z5Q8rxBVHu
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NE systems reach their lowest output during sleep and spike on waking, but I'll have to check if they lead or lag. I wonder if a anthropomorphic rendering would be 'energy'. I also wonder what the relationship between NE and autonomic behaviors is, mainly yawning.
I'll be looking for experiments with microinjections, broad injections, and blocking of NE. I'll also be looking at what happens when NE systems are neurochemically lesioned. NE systems are so broad so I'm maybe expecting it to be hard to find clean delineations.
I followed up on a hunch that melatonin and norepinephrine would have biochemical coupling. "In vertebrates, melatonin secretion is regulated by activation of the beta-1 adrenergic receptor by norepinephrine." Happy I'm finally using my biochem training.
Dopamine is the precursor for norepinephrine synthesis and I just found melatonin's precursor is serotonin. From a systems biology perspective these relationship set up dynamic systems. Put another way, these are chemical circuits.
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