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"Removal of the pituitary gland in rats induces a sever defect in the rate of acquisition of a pain-motivated active avoidance response (de Wied 1969)"
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"Administration of ACTH [synthesized in the pituitary] ... restores avoidance learning." ACHT is adrenocorticotropic hormone And it regulates levels of the steroid hormone cortisol
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Hypothesis put forward: ACTH-MSH exerts a general excitatory effect and augments fear responses.
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Conditioned fear, learning, and memory are both moderated by glutemate. I wonder if conditioned fear and learning are fundamentally different processes.
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In rats they tested avoidance behavior in "shuttleboxes", "jump boxes", or "a pole jumping test" sounds unpleasant and annoying but not necessarily fear inducing. Is there learning research on rats with no pituitary who are then stimulated to fear with cat urine (Unconditional)?
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Paanksepp describes fear in rats recognizably: trembling, hiding, cowering, fleeing, and bowel voiding. All relatable stuff.
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Rat Experiment: +/- pituitary Cat urine to stimulate unconditioned fear response in area of cage, see if associative learning fear of the area is conserved in -rats
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Very interested if ACTH is generally excitatory wrt learning unpleasant/fearful stimuli. Has implications for human behavior. Theres got to be more recent research.
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"Nasty little Buddhist"
Seeking via neuroscience and psychology informed dharma.