"On Sunday [WHO] published a scientific brief examining the evidence surrounding BCG. It concludes that there currently is no proof the vaccine protects against the new coronavirus. 'In the absence of evidence, WHO does not recommend BCG vaccination [for] COVID-19'"
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"[CEPI] collaboration that wants to re-engineer a measles vaccine so that it produces a immunizing SARS-CoV-2 protein in the body... It’s possible that measles vaccine-manufacturing facilities could be used to make a COVID-19 vaccine"
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With immunization missions already shuttered because of the pandemic, deferred production capacity will worsen impending outbreaks — like that of Ebola or Measles. "She cautions that it’s likely that capacity would have to be increased so as not to disrupt the original focus."
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"Other elements in the manufacturing process might create bottlenecks. ‘Subunit’ vaccines, which are composed of a SARS-CoV-2 protein, or a key fragment of one, often need an adjuvant... These might require ingredients that could become scarce during a pandemic"
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"Another idea to grow vaccines quickly is using plants. Cigarette giant British American Tobacco (BAT) said in April that it aims to grow vaccines (being developed by its subsidiary Kentucky BioProcessing) in fast-growing tobacco plants."
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While governments are rambling about plans to reopen their economies, they still haven't funded CEPI. "CEPI says that global funding of at least US$2 billion is needed to help develop candidate vaccines and manufacture them for trials, of which it has been promised $690 million"
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And given that POTUS has said he would defund the World Health Organization, will he do the same and cut any CEPI funding? Will he get jealous of their progress over the NIH's, or fear other countries will get a vaccine first — and deter their efforts?https://www.statnews.com/2020/04/15/whos-tedros-expressing-regret-over-trump-move-to-cut-funding-says-his-focus-on-is-saving-lives/ …
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"Congressional Democrats alleged Wednesday it would be illegal for President Trump to withhold money from the World Health Organization, igniting a dispute that echoed the impeachment showdown over Trump’s delay of security assistance to Ukraine."https://www.washingtonpost.com/us-policy/2020/04/15/trump-who-democrats/ …
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“We are reviewing all of our options, including asking GAO for an opinion given their opinion that the President’s hold on Ukraine funding was illegal.”
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"House Democrats contended Trump does not have the authority to block the remainder of the assessed contribution from being paid out to the WHO."
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"[Senior administration officials said] the structure of the appropriations law in question allows Trump to spend the remaining $60 million on any international organization, not just the WHO, as long as it is spent by the end of the fiscal year on Sept. 30."
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While therapeutics have lagged behind where they need to be, doctors are picking up the pace and experimenting. Healthcare workers have lost a lot of patients, but they also learned from them — and those lessons are saving more lives just days later. https://www.nytimes.com/2020/04/14/nyregion/new-york-coronavirus.html …
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"Instead of quickly sedating people who had low levels of oxygen & then putting them on ventilators, many doctors are now keeping patients conscious, having them roll over, recline in chairs & continue to breathe on their own — w/ additional oxygen — for as long as possible"
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"The idea is to get them off their backs and thereby make more lung available. A number of doctors are even trying patients on a special massage mattress designed for pregnant women because it has cutouts that ease the load on the belly and chest."pic.twitter.com/GrWFgpzZtA
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“Never in my life have I had to ask a patient to get off the telephone because it was time to put in a breathing tube" "Yet many Covid-19 patients remain alert, even when their oxygen has drastically fallen, for reasons health care workers can only guess."
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Proning is the NPI than I've heard is really making a difference. "Some patients, by taking oxygen and rolling onto their sides or on their bellies, have quickly returned to normal levels. The tactic is called proning."
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"At Lincoln Hospital in the Bronx, Dr. Nicholas Caputo followed 50 patients who arrived with low oxygen levels between 69 and 85% (95 is normal). After five minutes of proning, they had improved to a mean of 94%. Over the next 24hrs, nearly 3/4 were able to avoid intubation"
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“Intubated patients with Covid lung disease are doing very poorly, and while this may be the disease and not the mechanical ventilation, most of us believe that intubation is to be avoided until unequivocally required"
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The official numbers have risen by 50% after reports arose of families collecting urns in long lines for days at several Wuhan crematoriums.https://twitter.com/Rover829/status/1250984885365293057?s=20 …
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"Delays and omissions of cases"https://twitter.com/Rover829/status/1250985050289496065?s=20 …
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A really notable gap in the data that would imply suspected or confirmed cases never appeared in the death count.https://twitter.com/Nrg8000/status/1250986021996556288?s=20 …
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Here is the machine translation of the official statement on the Wuhan death count revision from Xinhua. It is notable that the Party sat on and concealed this recount investigation. https://wap.peopleapp.com/article/5397877/5311914 …pic.twitter.com/ExBqFWvaeH
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「生命至上,人民至上。每一个在疫情中逝去的生命是家庭之殇,更是城市铭心之痛。在此,我们谨向在新冠肺炎疫情期间病逝者家属致以诚挚慰问,向不幸罹难的同胞和牺牲的医务人员致以深切哀悼!」
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「一是疫情早期病人激增,导致医疗资源挤兑,收治能力严重不足,有些患者没有入院治疗,在家中病亡。二是在救治高峰期,医院超负荷运转,医务人员忙于救治,客观上存在迟报、漏报和误报现象。…… 少数医疗机构未能及时与大疫情网对接、报送信息。四是有些死亡病例信息登记不全,存在重报、误报情况」
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Miscounts are expected, especially in early days like Wuhan's. The on the ground reports speculated a higher death toll; some of those deaths would be from heart attacks & other baselines. But it is notable that these corrections came in 1 report. How long were the errors known?
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Like Iran, a really staggering miscount is occurring in Ecuador. Guayas has confirmed 187 deaths, but since January 1st, the province has recorded 14,561 — with 6,703 occurring in the first half of April. It typically averages just 2000 deaths per month.https://www.eluniverso.com/guayaquil/2020/04/16/nota/7815738/fallecidos-guayas-2020-coronavirus-registro-civil …
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The sheer amount of death is Guayaquil is shocking. It is theorized that Ecuador was the first to be hit so hard in Latin America because of its interconnectedness with Spain. https://www.eltiempo.com/mundo/latinoamerica/por-que-guayaquil-ha-sido-fuertemente-afectada-por-el-coronavirus-483784 …pic.twitter.com/ZU7jw2rog1
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"Cemeteries, crematories — funeral homes run out of coffins." "When they came to remove my father's body, we weren't given any documents, nothing....When they took the body they didn't use any label, documents, or anything to identify it. Nothing at all"https://youtu.be/x1s9NvV6dXk
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"I called 911 tirelessly, but I gave up since no one would offer any help."pic.twitter.com/MaMkIV7qqp
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