Insula is considered the “primary interoceptive cortex”. It’s hypothesized to integrate visceral-sensory info about current bodily state (hunger,thirst,temperature,etc) with previously learned info to potentially compute interoceptive predictions and prediction errors…2/7
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We followed-up on our previous work (https://www.nature.com/articles/nature22375 …) and imaged insular cortex population activity in hungry or thirsty mice as they gradually became sated. insular ongoing activity patterns reflected current bodily state, not behavioral state (arousal, motivation)… 3/7
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Insular cortex was not “fooled” by the hypothalamus: artificial activation of hypothalamic “hunger neurons” and “thirst neurons” in sated animals restored responses to learned food/water cues. BUT it did NOT affect ongoing activity, which still reflected to true bodily state…4/7
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But what do food/water predicting cues actually mean in insular cortex? We looked at the patterns of activity that these cues evoke and found that they drive a transient “simulation” of a future satiety state that would only occur hours later…5/7
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We speculate that these cortical “simulations” along different dimensions/axes of population activity serve to guide and prioritize behavior. For example, how will eating salty food when you’re both hungry and thirsty affect energy and fluid balance?…6/7pic.twitter.com/iXK2FKiwoj
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Thanks to everyone involved in the work and to the many people who took the time to give us insightful feedback. Please DM me if you don't have access to the paper. END 7/7
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Congrats Yoav!
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Thanks Amber!
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Congrats Yoav! Great to see this out!
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Thanks Dj!
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