Yu-Chieh David Chen

@YCDavidChen

Postdoc in Desplan's lab at NYU | Former PhD in Dahanukar's lab at UCR | HHMI international student fellow alumni | sensory neurobiology and development

Riverside, CA
Vrijeme pridruživanja: travanj 2016.

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  1. Prikvačeni tweet
    22. lis 2019.

    I’m excited to share our latest work on how pharyngeal taste neurons in adult flies avoid aversive substances, such as bitter, acid, and high salt. This story is now featured on the cover in Reports! Here are the main findings of this work…

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  2. proslijedio/la je Tweet
    15. sij

    Congrats to ! He is an awesome mentor and scientist!!

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  3. proslijedio/la je Tweet
    9. sij

    Happy to share our second paper on Ecdysone Importer (EcI) - the fly BBB requires this SLCO transporter to incorporate steroid hormones into the brain:

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  4. proslijedio/la je Tweet
    20. stu 2019.

    In the mood for some cool science talks? Join us for the November tomorrow (Nov 21st), 1:05-1:45 P.M. EST, featuring and . Join us here:

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    18. stu 2019.
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  6. 7. stu 2019.

    Happy to share my latest commentary article together with about the taste of negativity-anion-mediated salt transduction in mouse taste cells in See the original article in

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  7. proslijedio/la je Tweet
    24. lis 2019.

    Taste coding, in the pharynx, so that flies can avoid yucky food. Like canned peas. Yuck.

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  9. 22. lis 2019.

    Thanks to our collaborators Bill Ja and who perform the consumption and optogenetic experiments. Ryan Joseph for the pharyngeal calcium imaging. for the initial characterization that Poxn mutant flies retain functional pharyngeal taste neurons. 12/12

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  10. 22. lis 2019.

    Our work provides a foundation for further functional investigation of these “orphan” pharyngeal neurons and their higher-order taste circuits. 11/n

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  11. 22. lis 2019.

    Final thought, there are 24 neurons in the pharynx, yet we still don’t know their functions for many of them. I hope our work demonstrates an important role of pharyngeal taste in controlling food choice and intake. 10/n

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  12. 22. lis 2019.

    We found that single pharyngeal taste neurons showed connections with multiple second-order neurons that projected to two common areas (pars intercerebralis and lateral protocerebrum), suggesting that specific taste input may be broadly conveyed across several brain regions. 9/n

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  13. 22. lis 2019.

    To understand where these pharyngeal neurons convey taste information in the fly brain, we used trans-Tango to map the downstream neuronal circuits connecting each subset of pharyngeal neurons. 8/n

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  14. 22. lis 2019.

    The inhibition of pharyngeal sweet neurons together with the activation of different subsets of aversive pharyngeal neurons ensures appropriate feeding avoidance of aversive compounds. 7/n

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  15. 22. lis 2019.

    To go down the rabbit hole of pharyngeal taste coding, we silenced different pharyngeal neurons and checked the feeding behaviors. We found that food avoidance of bitter, acidic, and salty compounds is achieved via overlapping but distinct subsets of pharyngeal neurons. 6/n

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    22. lis 2019.

    Our collaboration with the Dahanukar lab and is finally out! 🥳 Pharyngeal neurons play a huge role in food consumption and preference! Honored to have been a part of this project 🙂

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  17. 22. lis 2019.

    Interestingly, activation of single aversive pharyngeal neurons suppresses food intake in different ways, such as reducing the meal size or increasing the time to the next meal. This is done by our excellent collaborators and Bill Ja at Scripps Florida. 5/n

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  18. 22. lis 2019.

    Using the chemoreceptor-to-neuron maps developed previously in 2017 , we found that pharyngeal taste neurons are responsible for mediating feeding avoidance of these aversive compounds. 4/n

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  19. 22. lis 2019.

    In many ways the feeding behaviors of Poxn mutant flies in food choice assays and consumptions assays are similar to that of wild type flies. Thus, the pharyngeal taste could only control the intensity of feeding aversion but also the suppression of food intake. 3/n

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  20. 22. lis 2019.

    We still don’t know why the pharyngeal neurons aren’t affected by Poxn mutation, but the mutant flies serve as a good model to study the function of pharyngeal taste. We first found that Poxn mutants with only pharyngeal taste respond to a broad range of aversive compounds. 2/n

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  21. 22. lis 2019.

    The story started with examining food choice behaviors of Poxn mutant flies in which all “external” chemosensory hairs are lost but all internal pharyngeal taste neurons are intact. 1/n

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