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Prikvačeni tweet
I’m excited to share our latest work on how pharyngeal taste neurons in adult flies avoid aversive substances, such as bitter, acid, and high salt. This story is now featured on the cover in
@Cell Reports! https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31224-0#.Xa9AvJCwnrY.twitter … Here are the main findings of this work…Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Yu-Chieh David Chen proslijedio/la je Tweet
Congrats to
@ClaudeDesplan ! He is an awesome mentor and scientist!!https://twitter.com/Planaria1/status/1217562568665042944 …
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Yu-Chieh David Chen proslijedio/la je Tweet
Happy to share our second paper on Ecdysone Importer (EcI)
@CurrentBiology - the fly BBB requires this SLCO transporter to incorporate steroid hormones into the brain:https://www.cell.com/current-biology/fulltext/S0960-9822(19)31587-8# …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Yu-Chieh David Chen proslijedio/la je Tweet
In the mood for some cool science talks? Join us for the November
@GeneticsGSA#ECRseminar tomorrow (Nov 21st), 1:05-1:45 P.M. EST, featuring@jlsteenwyk and@YCDavidChen. Join us here: https://global.gotomeeting.com/join/743024653 pic.twitter.com/F47o7lguDW
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Yu-Chieh David Chen proslijedio/la je Tweet
New Research: Commentary: The Role of the Anion in Salt (NaCl) Detection by Mouse Taste Buds https://www.frontiersin.org/articles/10.3389/fncel.2019.00502?utm_source=S-TWT&utm_medium=SNET&utm_campaign=ECO_FNINS_XXXXXXXX_auto-dlvrit …
#neuroscienceHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Happy to share my latest commentary article together with
@the_menonknight about the taste of negativity-anion-mediated salt transduction in mouse taste cells in@FrontNeurosci https://doi.org/10.3389/fncel.2019.00502 … See the original article in@SfNJournalshttps://doi.org/10.1523/JNEUROSCI.2367-18.2019 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Yu-Chieh David Chen proslijedio/la je Tweet
Taste coding, in the pharynx, so that flies can avoid yucky food. Like canned peas. Yuck.http://bit.ly/32JGPjj
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Yu-Chieh David Chen proslijedio/la je Tweet
How taste neurons are gatekeepers for food intake, using
#optogenetics and model organism w/ mutations https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31224-0 …@CellReports#openaccess@UCRiversidepic.twitter.com/kJD5M4Imwj
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Thanks to our collaborators Bill Ja and
@scarletjpark who perform the consumption and optogenetic experiments. Ryan Joseph for the pharyngeal calcium imaging.@Gordonflylab for the initial characterization that Poxn mutant flies retain functional pharyngeal taste neurons. 12/12Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Our work provides a foundation for further functional investigation of these “orphan” pharyngeal neurons and their higher-order taste circuits. 11/n
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Final thought, there are 24 neurons in the pharynx, yet we still don’t know their functions for many of them. I hope our work demonstrates an important role of pharyngeal taste in controlling food choice and intake. 10/n
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We found that single pharyngeal taste neurons showed connections with multiple second-order neurons that projected to two common areas (pars intercerebralis and lateral protocerebrum), suggesting that specific taste input may be broadly conveyed across several brain regions. 9/n
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To understand where these pharyngeal neurons convey taste information in the fly brain, we used trans-Tango to map the downstream neuronal circuits connecting each subset of pharyngeal neurons. 8/n
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The inhibition of pharyngeal sweet neurons together with the activation of different subsets of aversive pharyngeal neurons ensures appropriate feeding avoidance of aversive compounds. 7/n
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To go down the rabbit hole of pharyngeal taste coding, we silenced different pharyngeal neurons and checked the feeding behaviors. We found that food avoidance of bitter, acidic, and salty compounds is achieved via overlapping but distinct subsets of pharyngeal neurons. 6/n
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Yu-Chieh David Chen proslijedio/la je Tweet
Our collaboration with the Dahanukar lab and
@YCDavidChen is finally out!
Pharyngeal neurons play a huge role in food consumption and preference! Honored to have been a part of this project
https://twitter.com/YCDavidChen/status/1186710832895250432 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Interestingly, activation of single aversive pharyngeal neurons suppresses food intake in different ways, such as reducing the meal size or increasing the time to the next meal. This is done by our excellent collaborators
@scarletjpark and Bill Ja at Scripps Florida. 5/nPrikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Using the chemoreceptor-to-neuron maps developed previously
@CellReports in 2017 https://www.sciencedirect.com/science/article/pii/S2211124717316789 …, we found that pharyngeal taste neurons are responsible for mediating feeding avoidance of these aversive compounds. 4/nPrikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
In many ways the feeding behaviors of Poxn mutant flies in food choice assays and consumptions assays are similar to that of wild type flies. Thus, the pharyngeal taste could only control the intensity of feeding aversion but also the suppression of food intake. 3/n
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We still don’t know why the pharyngeal neurons aren’t affected by Poxn mutation, but the mutant flies serve as a good model to study the function of pharyngeal taste. We first found that Poxn mutants with only pharyngeal taste respond to a broad range of aversive compounds. 2/n
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The story started with examining food choice behaviors of Poxn mutant flies in which all “external” chemosensory hairs are lost but all internal pharyngeal taste neurons are intact. 1/n
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