Xavier Trepat

@XavierTrepat

ICREA Research Professor, Scientist of Living Matter, Group Leader . Jazz trombone with

Vrijeme pridruživanja: siječanj 2015.

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  1. prije 22 sata

    Stretch activates ERK through epidermal growth factor receptor (EGFR), and the ERK activation triggers cell contraction. Then, the contraction of the activated cell pulls neighboring cells via cell-cell junctions, evoking another round of ERK activation

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  2. prije 22 sata

    In case you’ve missed it, here’s a beautiful example of a closed mechanochemical feedback loop by Tsuyoshi Hirashima’s lab. Collective migration, waves, FRET sensors, ... and some mechanical tools from our lab!

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  3. 24. sij

    “When cellular forces became visible”. I wrote this short piece on the paper that, in my opinion, started the field of quantitative cell mechanics: Harris, Wild and Stopak, Science, 1980.

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  4. 17. sij

    I discovered today Nature Reviews Disease Primers (not a new journal). Looks really useful! For example, check out this recent general review on Breast Cancer

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  5. proslijedio/la je Tweet
    14. sij

    Our PCTS workshop 'The Physics of Collective Cell Migration' starts tomorrow! If you can't come, you can follow it via live streaming at

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    10. sij

    We released a plugin for ! 🎉 It ships with a versatile model that we found to work well for segmenting cell nuclei in a variety of challenging (2D) fluorescence microscopy images. 🌟

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    9. sij
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  8. 8. sij

    For those of you who were on twitter diet during holidays, this is your opportunity to complete this threat with your preferred mechanobiology papers in 2019. 👇

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  9. 8. sij

    A DNA-based ratiometric fluorescent probe to quantify intercellular tensile forces. Works by incubation with target cells with no need for transfection. It confirms a gradient in cell-cell tension previously measured with monolayer stress microscopy.

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  10. 23. pro 2019.

    DJ Daniel Cohen makes cells dance on demand using bioelectrical stimulation. Lines, flips, turns, circles… Don’t miss their movies! 🔝🔝🔝

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  11. proslijedio/la je Tweet
    21. pro 2019.

    Some thoughts on one of my favourite mechanobiology paper from 2019: epithelial sheets are everywhere in our body and it is vital for their function to stay flat. But how do they avoid buckling under ubiquitous compression?

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  12. 20. pro 2019.

    By the way, it seems that the paper by AK Harris made it to the cover of in 1980, which I find a quite visionary choice by the journal. Any chance for a high-resolution version?

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  13. 20. pro 2019.

    The second one, much less cited, was by J Harris (a different Harris) at the on the locomotion of crickets, cockroaches and grasshoppers. He used photoelastic substrate transduction.

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  14. 20. pro 2019.

    As I was preparing my , I discovered there are two papers on the study of cell locomotion and substrate tractions published by Harris et al in 1980. One is the legendary work by AK Harris that started it all.

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  15. 19. pro 2019.

    And this one by Segel et al because it shows that brain progenitor cells can be rejuvenated by culturing them on synthetic scaffolds that mimic the stiffness of young brains.

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  16. 19. pro 2019.

    For example, I liked this paper by Dumortier et al because it shows the morphogenetic power of water.

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  17. 19. pro 2019.

    👀Let’s build a with some memorable papers published in 2019 in the field of . With 1-2 sentences explaining why we highlight them. 👇

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  18. proslijedio/la je Tweet
    18. pro 2019.

    UC 's Y.C. Fung, the lifesaving 'father of biomechanics', dies at 100

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  19. proslijedio/la je Tweet
    16. pro 2019.

    Our work on how the shape of liquid droplets can be sculpted by incorporating biopolymers is now up BioRxiv! Let by postdoc Kim Weirich and grad student Danielle Scheff!

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  20. 16. pro 2019.

    📢We’re hiring! Looking for one postdoc to work on engineering the shape and mechanobiology of and in 3D. Starting first half of 2020‼️ Background in and any possible mixture between those.

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