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Stretch activates ERK through epidermal growth factor receptor (EGFR), and the ERK activation triggers cell contraction. Then, the contraction of the activated cell pulls neighboring cells via cell-cell junctions, evoking another round of ERK activation
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In case you’ve missed it, here’s a beautiful example of a closed mechanochemical feedback loop by Tsuyoshi Hirashima’s lab. Collective migration, waves, FRET sensors,
#optogenetics... and some mechanical tools from our lab! https://www.biorxiv.org/content/10.1101/2019.12.25.888552v1 …pic.twitter.com/jQrsomin4YPrikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
“When cellular forces became visible”. I wrote this short piece
@NatRevMCB on the paper that, in my opinion, started the field of quantitative cell mechanics: Harris, Wild and Stopak, Science, 1980. https://www.nature.com/articles/s41580-020-0216-1 …pic.twitter.com/w6NO0CtigE
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I discovered today Nature Reviews Disease Primers (not a new journal).
@DiseasePrimers https://www.nature.com/nrdp/ Looks really useful! For example, check out this recent general review on Breast Cancer https://www.nature.com/articles/s41572-019-0111-2 …pic.twitter.com/V9Yfbbedci
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Xavier Trepat proslijedio/la je Tweet
Our PCTS workshop 'The Physics of Collective Cell Migration' starts tomorrow! If you can't come, you can follow it via live streaming at http://www.kaltura.com/tiny/jxaqm pic.twitter.com/nCTi07V56G
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Xavier Trepat proslijedio/la je Tweet
We released a
#StarDist plugin for@FijiSc!
https://imagej.net/StarDist
It ships with a versatile model that we found to work well for segmenting cell nuclei in a variety of challenging (2D) fluorescence microscopy images.
#WeAreStarDistpic.twitter.com/bu4IUb5jyn
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Xavier Trepat proslijedio/la je Tweet
Interested in an exciting post-doc project in the happiest country in the world - Finland ? https://www.independent.co.uk/travel/news-and-advice/happiest-countries-world-2019-winner-finland-bhutan-denmark-norway-iceland-a8831576.html … Apply to the open
@IvaskaLab positions https://www.utu.fi/en/university/come-work-with-us/open-vacancies …pic.twitter.com/cw4Gg6W7BI
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For those of you who were on twitter diet during holidays, this is your opportunity to complete this threat with your preferred mechanobiology papers in 2019.
https://twitter.com/XavierTrepat/status/1207930456571863041 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
A DNA-based ratiometric fluorescent probe to quantify intercellular tensile forces. Works by incubation with target cells with no need for transfection. It confirms a gradient in cell-cell tension previously measured with monolayer stress microscopy. https://www.biorxiv.org/content/10.1101/2020.01.07.897249v1 …pic.twitter.com/OoE4Z3A6DW
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DJ Daniel Cohen
@Princeton makes cells dance on demand using bioelectrical stimulation. Lines, flips, turns, circles… Don’t miss their movies!

https://www.biorxiv.org/content/10.1101/2019.12.20.884510v1 …pic.twitter.com/bBa1luTgNgHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Xavier Trepat proslijedio/la je Tweet
Some thoughts on one of my favourite mechanobiology paper from 2019: epithelial sheets are everywhere in our body and it is vital for their function to stay flat. But how do they avoid buckling under ubiquitous compression?https://www.nature.com/articles/s41563-019-0543-9 …
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By the way, it seems that the paper by AK Harris made it to the cover of
@sciencemagazine in 1980, which I find a quite visionary choice by the journal. Any chance for a high-resolution version?pic.twitter.com/qakOW9hllw
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The second one, much less cited, was by J Harris (a different Harris) at the
@J_Exp_Biol on the locomotion of crickets, cockroaches and grasshoppers. He used photoelastic substrate transduction. https://jeb.biologists.org/content/85/1/263.short …pic.twitter.com/oQiBhlCeSj
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As I was preparing my
#journalclub, I discovered there are two papers on the study of cell locomotion and substrate tractions published by Harris et al in 1980. One is the legendary work by AK Harris@sciencemagazine that started it all. https://science.sciencemag.org/content/208/4440/177 …pic.twitter.com/ZxtF1ZPd1F
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And this one by Segel et al because it shows that brain progenitor cells can be rejuvenated by culturing them on synthetic scaffolds that mimic the stiffness of young brains.
#aging#MechbioHighlights19@naturepic.twitter.com/OkCOtU6q8s
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For example, I liked this paper by Dumortier et al because it shows the morphogenetic power of water. https://science.sciencemag.org/content/365/6452/465.long …
#MechbioHighlights19@sciencemagazinepic.twitter.com/V4yGBAQ42t
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Let’s build a #thread with some memorable papers published in 2019 in the field of#Mechanobiology. With 1-2 sentences explaining why we highlight them.#MechbioHighlights19
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Xavier Trepat proslijedio/la je Tweet
UC
#SanDiego's Y.C. Fung, the lifesaving 'father of biomechanics', dies at 100 http://dlvr.it/RLXsfC pic.twitter.com/iNp2l1S46F
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Xavier Trepat proslijedio/la je Tweet
Our work on how the shape of liquid droplets can be sculpted by incorporating biopolymers is now up BioRxiv! https://doi.org/10.1101/2019.12.13.876003 … Let by postdoc Kim Weirich and grad student Danielle Scheff!
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We’re hiring! Looking for one postdoc to work on engineering the shape and mechanobiology of #organoids and#tumoroids in 3D. Starting first half of 2020
Background in #physics#engineering#biology and any possible mixture between those.pic.twitter.com/hhoN3bYOGi
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