It displays a common misunderstanding - that if genetic variants are associated with a trait, then they must be revealing some proximal *biological mechanism*. This is not the case.
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Odgovor korisnicima @WiringTheBrain @AdamRutherford
Of course, for some traits and some variants, there is a direct molecular mechanism underlying the association. (Think of eye colour, for example).
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Odgovor korisnicima @WiringTheBrain @AdamRutherford
But for complex traits (and especially for social outcomes), the effects of genetic differences may also be mediated through environmental or cultural mechanisms
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Odgovor korisnicima @WiringTheBrain @AdamRutherford
For educational attainment, we know this is the case. As described here, for example: The nature of nurture: Effects of parental genotypes https://science.sciencemag.org/content/359/6374/424 …pic.twitter.com/17ii3ufT8D
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Odgovor korisnicima @WiringTheBrain @AdamRutherford
...which showed effects on educational attainment of parental genotypes that were NOT transmitted to the offspring (i.e., mediated by "nurture")pic.twitter.com/tHDiX9BQIr
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Odgovor korisnicima @WiringTheBrain @AdamRutherford
Similarly: Social Competence in Parents Increases Children's Educational Attainment: Replicable Genetically-Mediated Effects of Parenting... https://www.ncbi.nlm.nih.gov/pubmed/30661510 pic.twitter.com/kN2rFTQXe5
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Odgovor korisnicima @WiringTheBrain @AdamRutherford
Comparison of adopted and non-adopted individuals reveals gene-environment interplay for education in the UK Biobank https://www.biorxiv.org/content/10.1101/707695v1 …pic.twitter.com/VkuzDPAYz6
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Odgovor korisnicima @WiringTheBrain @AdamRutherford
So, the idea that polygenic scores for social traits somehow give you a pure look at innate *biological mechanisms* is simply wrong.
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Odgovor korisnicima @WiringTheBrain @AdamRutherford
There will always be a complex interplay of innate predispositions, family environment and societal and cultural factors, often acting in amplifying loops...
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Odgovor korisnicima @WiringTheBrain @AdamRutherford
As discussed here: Nature versus nurture: how modern science is rewriting it https://theconversation.com/nature-versus-nurture-how-modern-science-is-rewriting-it-127472?utm_source=twitter&utm_medium=bylinetwitterbutton … via
@ConversationUK11 proslijeđenih tweetova 45 korisnika označava da im se sviđa
More than most traits, educational attainment is strongly influenced by the "Matthew effect": For to every one who has will more be given, and he will have abundance; but from him who has not, even what he has will be taken away. — Matthew 25:29pic.twitter.com/RJ8CzVx4hQ
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