Mendelian randomization, bariatric surgery, & weight loss studies show decreases all cause mortality. Strongest causal evidence. Then epi associating obesity w bad things. If you use things like [heaviest BMI] u get over the [cancer causes weight loss]-->[verylowBMI-->high death]
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Replying to @Willy_Chertman @alexeyguzey
Which can sometimes occur. Excess bodyfat is also causal for type 2 diabetes, and sustained substantial weight loss -->DM2 remission in many patients, A1C reduction in patients. Excess energy --> obesity w/hyperinsulinemia and normal sugar-->insulin resist-->Dm2 rough model
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Replying to @Willy_Chertman
Alexey Guzey Retweeted Alexey Guzey
Alexey Guzey added,
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Replying to @Willy_Chertman
looked at your first link. it's a review of something related to my question, not the answer to the question, neither it is a review of papers that try to answer the questions. if you think that it cites studies that try to answer my question, please link them directly
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Replying to @alexeyguzey @Willy_Chertman
link 2 does not seem to discuss mortality at all? this is weird link 3 does not seem to have any clinical trials at all? an RCT of bariatric surgery that would look at effect on mortality would be perfect...
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Replying to @alexeyguzey @Willy_Chertman
(but reversal of diabetes type 2 via weight reduction is actually a good point)
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Replying to @alexeyguzey
Apologies. Looked through that again. 1: good evidence weight loss -->reduce DM2. The bariatric surgery stuff wasn't true RCT. Seems to be matching patients w/ controls. Didn't see any sham surgery controls. But I think blinding is overrated as a problem in objective measure
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Replying to @Willy_Chertman @alexeyguzey
Though the lack of randomization (I think? Didn't look in detail) is a big problem
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But the lifestyle-->weight loss stuff WAS randomized, so I think if bariatric surgery causes weight loss, not a big stretch to say it also has effects of lifestyle modification
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