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Willy_Chertman's profile
Willy Chertman
Willy Chertman
Willy Chertman
@Willy_Chertman

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Willy Chertman

@Willy_Chertman

MD student, 3rd year @UMiami. Genetics, longevity, open science, and OB/Gyn (?)

United States
Joined July 2014

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    1. Alexey Guzey‏ @alexeyguzey Mar 5

      is there any non-correlational evidence that obesity is unhealthy?

      17 replies 3 retweets 25 likes
      Show this thread
    2. Willy Chertman‏ @Willy_Chertman Mar 5
      Replying to @alexeyguzey

      Mendelian randomization, bariatric surgery, & weight loss studies show decreases all cause mortality. Strongest causal evidence. Then epi associating obesity w bad things. If you use things like [heaviest BMI] u get over the [cancer causes weight loss]-->[verylowBMI-->high death]

      1 reply 0 retweets 0 likes
    3. Willy Chertman‏ @Willy_Chertman Mar 5
      Replying to @Willy_Chertman @alexeyguzey

      Which can sometimes occur. Excess bodyfat is also causal for type 2 diabetes, and sustained substantial weight loss -->DM2 remission in many patients, A1C reduction in patients. Excess energy --> obesity w/hyperinsulinemia and normal sugar-->insulin resist-->Dm2 rough model

      1 reply 0 retweets 0 likes
    4. Alexey Guzey‏ @alexeyguzey Mar 6
      Replying to @Willy_Chertman

      Alexey Guzey Retweeted Alexey Guzey

      links? alsohttps://twitter.com/alexeyguzey/status/1235906106054135808 …

      Alexey Guzey added,

      Alexey Guzey @alexeyguzey
      Replying to @SilverVVulpes
      links? i just read about mendelian randomization and it sounds shady as shit tbh; like way too many assumptions about our knowledge of biological mechanisms to take it seriously.... am i wrong?
      1 reply 0 retweets 0 likes
    5. Willy Chertman‏ @Willy_Chertman Mar 6
      Replying to @alexeyguzey

      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777230/ … https://www.mdpi.com/2072-6643/11/4/766 … https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055056/#S3title …

      1 reply 0 retweets 0 likes
    6. Alexey Guzey‏ @alexeyguzey Mar 6
      Replying to @Willy_Chertman

      looked at your first link. it's a review of something related to my question, not the answer to the question, neither it is a review of papers that try to answer the questions. if you think that it cites studies that try to answer my question, please link them directly

      1 reply 0 retweets 0 likes
    7. Alexey Guzey‏ @alexeyguzey Mar 6
      Replying to @alexeyguzey @Willy_Chertman

      link 2 does not seem to discuss mortality at all? this is weird link 3 does not seem to have any clinical trials at all? an RCT of bariatric surgery that would look at effect on mortality would be perfect...

      1 reply 0 retweets 0 likes
    8. Alexey Guzey‏ @alexeyguzey Mar 6
      Replying to @alexeyguzey @Willy_Chertman

      (but reversal of diabetes type 2 via weight reduction is actually a good point)

      1 reply 0 retweets 0 likes
    9. Alexey Guzey‏ @alexeyguzey Mar 6
      Replying to @alexeyguzey @Willy_Chertman

      oh ofchttps://clinicaltrials.gov/ct2/results?cond=Obesity&term=surgery&cntry=&state=&city=&dist= …

      2 replies 0 retweets 0 likes
      Willy Chertman‏ @Willy_Chertman Mar 6
      Replying to @alexeyguzey

      Apologies. Looked through that again. 1: good evidence weight loss -->reduce DM2. The bariatric surgery stuff wasn't true RCT. Seems to be matching patients w/ controls. Didn't see any sham surgery controls. But I think blinding is overrated as a problem in objective measure

      5:10 AM - 6 Mar 2020
      1 reply 0 retweets 0 likes
        1. New conversation
        1. Willy Chertman‏ @Willy_Chertman Mar 6
          Replying to @Willy_Chertman @alexeyguzey

          Though the lack of randomization (I think? Didn't look in detail) is a big problem

          1 reply 0 retweets 0 likes
        2. Willy Chertman‏ @Willy_Chertman Mar 6
          Replying to @Willy_Chertman @alexeyguzey

          But the lifestyle-->weight loss stuff WAS randomized, so I think if bariatric surgery causes weight loss, not a big stretch to say it also has effects of lifestyle modification

          0 replies 0 retweets 0 likes
          3. End of conversation

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