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WillManidis's profile
Will Manidis
Will Manidis
Will Manidis
@WillManidis

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Will Manidis

@WillManidis

ceo @ScienceDotIO

Cambridge, MA
willmanidis.com
Joined September 2016

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    1. John Carroll‏Verified account @JohnCendpts 19 Oct 2020

      Super-secretive anti-aging biotech Calico tees up the first visible clinical trial of an experimental drug. And it’s for cancer?https://endpts.com/super-secretive-anti-aging-biotech-calico-tees-up-the-first-visible-clinical-trial-of-an-experimental-drug-and-its-for-cancer/ …

      4 replies 15 retweets 43 likes
    2. William Gibson‏ @wgibson 19 Oct 2020
      Replying to @JohnCendpts

      Not surprising to me. @UnityBiotech @NathanielEDavid program has been MDM2 inhibitors. To me, the aging narrative is: DNA damage -> p53 activation -> cell cycle arrest -> senescence (p16, SA-B-gal accumulate) -> SASP -> macro-aging phenotype as emergent phenomenon.

      2 replies 1 retweet 6 likes
      Will Manidis‏ @WillManidis 19 Oct 2020
      Replying to @wgibson @JohnCendpts and

      heavily agree with this take

      8:27 AM - 19 Oct 2020
      1 reply 0 retweets 0 likes
        1. William Gibson‏ @wgibson 19 Oct 2020
          Replying to @WillManidis @JohnCendpts and

          watch this space!

          0 replies 0 retweets 0 likes
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