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    Interesting phenomenon that also happens during development. ERV activation stimulates activation of ERV repressors👇🏼

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  2. proslijedio/la je Tweet
    2. velj

    Our new review/perspective on understanding the physical basis for phase separation of biomolecules is online today: Although technically a review, we've used this to outline the contours of a general framework we've been working on for a while now.

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    31. sij

    Brief summary of our recent paper: Rewiring of endogenous signaling pathways to genomic targets for therapeutic cell reprogramming Congratulations to my friend and former colleague Krzysztof Krawczyk! (1)

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    29. sij

    Our latest collaboration with Falco lab is out. Retinoic Acid brings back to 2cell-like stage by tuning - expression

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    25. sij
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    24. sij

    This is a great paper from group on the comparison head to head of WT Cas9, xCas9, Cas9-NG & a new variant xCas9-NG for KO, activation & repression in K562 cells. Unsurprisingly WT Cas9 outperforms PAM flexible variants. xCas9-NG is not bad

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    24. sij
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    23. sij

    Here is my last work in the ! Dux is important for proper pre-implantation embryo development, but some murine zygotes can develop to healthy adults without it!

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    18. sij

    Why not spend the long weekend reading a preprint on zinc finger gene evolution and their roles in TE silencing!

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    Biologists say they need clearer guidelines on funding rules for this nascent field.

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    16. sij

    ISSCR statement on ethical standards for stem cell-based embryo models recognizes advances in the field and the scientific community's need to address these new challenges and to establish parameters for research.

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    16. sij

    Work with human stem cells to create embryos is moving forward without ethical guidelines for oversight. A new paper underscores the issues and importance of developing them, globally by Insoo Hyun and colleagues

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  14. proslijedio/la je Tweet
    15. sij

    Happy to share our preprint on the requirement of Sox2 for the induction, maintenance and differentiation of naïve pluripotency. With

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    14. sij

    CRISPR-Cas13d induces efficient mRNA knock-down in animal embryos All right, first story from the Moreno-Mateos lab. A great collaboration with the . Do you wanna induce knock-down in zebrafish and other animal embryos? Take a look to it :)

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    14. sij

    Our new review has been accepted for publication.

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  17. proslijedio/la je Tweet
    13. sij

    Exciting new research from explores NELFA as one of the earliest drivers of the 2C-like state in mouse embryonic

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  18. proslijedio/la je Tweet
    13. sij

    SETDB1-mediated cell fate transition between 2C-like and states.

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  19. proslijedio/la je Tweet
    2. sij

    What happens when stem cells experience replication stress and activate ATR? They expand cell fate potential! Take a look at our first preprint: "ATR expands embryonic stem cell fate potential in response to replication stress"

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  20. proslijedio/la je Tweet
    7. sij

    First pub of the new year from the lab. "Recording mobile DNA in the gut microbiota using an Escherichia coli CRISPR-Cas spacer acquisition platform" The HGT data is pretty amazing to me even now. Led by & .

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