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Prikvačeni tweet
Our work was published regarding loss of acidity in the yeast lysosome-like vacuole resulting in age-associated iron sulfur cluster defects. Lots of hard work by many amazing people.
@mkaeberlein@crane_mm@UHCL#UHCL#mitochondria#lysosome#gerosciencehttps://link.springer.com/article/10.1007/s11357-020-00159-3 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Brian M. Wasko, PhD proslijedio/la je Tweet
A good day for iron, lysosomes, and lab coordination. Cool work from
@KivancBirsoy showing maintenance of iron homeostasis is critical function of lysosomes. Compliments our paper published today@CellCellPress and work from@WaskoBM and@nunoraimundo.https://twitter.com/KivancBirsoy/status/1220385847972892673 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Work from the
@Adam_L_Hughes lab with some similar initial findings published@CellCellPress the same day! (though our stories diverge in very interesting ways)https://www.cell.com/cell/fulltext/S0092-8674(19)31397-2 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Brian M. Wasko, PhD proslijedio/la je Tweet
Excited to share our recent work exploring the underlying mechanisms connecting lysosome and mitochondrial function in aging. https://www.cell.com/cell/fulltext/S0092-8674(19)31397-2 …
@CellCellPress@casey_e_hughes@CoodyTroy@jordanberg0@UUtah#aminoacidtoxicity#mitochondria#lysosomePrikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
We then looked for similar effects with age using microfluidics and found defects in iron-sulfur cluster proteins. At the single cell level there was divergent response to this crisis with some cells having a compensatory iron transcriptional response while other cells didn’t.
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We used yeast mutants missing the conserved vacuolar ATPase H+ pump (V-ATPase) that acidifies the vacuole to model loss of lysosomal/vacuolar acidity that occurs during aging. Using unbiased genetic screens, we found iron dyshomeostasis was important in V-ATPase mutants.
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Put a paper on biorxiv. Loss of vacuolar acidity results in iron sulfur cluster defects and divergent homeostatic responses during aging in Saccharomyces cerevisiaehttps://www.biorxiv.org/content/10.1101/2020.01.05.895433v1 …
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Brian M. Wasko, PhD proslijedio/la je Tweet
Rapamycin rejuvenates oral health in aging mice! New preprint from a collab between @mkaeberlein &@KaczorowskiLab is out now. More in@newscientist: https://institutions.newscientist.com/article/2227421-anti-ageing-drug-rejuvenates-the-mouths-and-oral-microbiome-of-mice/ …pic.twitter.com/7mnEEOCVsE
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Brian M. Wasko, PhD proslijedio/la je Tweet
We are pleased to announce that Translational Medicine of Aging is now indexed by the Scopus. http://ow.ly/Vywi50xsveF pic.twitter.com/kzv2fSca5r
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Brian M. Wasko, PhD proslijedio/la je Tweet
Review commons, a journal-independent mechanism for peer review announced at
#ASCBEMBO2019. An exciting new step forward in the publishing revolution!https://www.reviewcommons.org/Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Brian M. Wasko, PhD proslijedio/la je Tweet
Five years ago, I reported 800 scientific papers with image duplications to journals. As of today, only one third of these have been corrected/retracted. Journals/institutions are very reluctant to take action. Maybe posting these duplications in public will help?
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Brian M. Wasko, PhD proslijedio/la je Tweet
Amazing! “After the CRISPR therapy, Gray’s total hemoglobin reached normal levels; of which 47% was fetal hemoglobin. It’s thought that a fetal hemoglobin level of 25%-30% is sufficient to “cure” a patient with sickle cell disease.“ New era of single, transformative therapieshttps://twitter.com/adamfeuerstein/status/1196760642969112578 …
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Brian M. Wasko, PhD proslijedio/la je Tweet
Xuetao Cao is China's biggest star scientist. He is Academician, Army general, member of
@EMBO,@Leopoldina,@nature Lifetime Achievement Award winner... And@MicrobiomDigest uncovered massive data manipulation in >50 of his papers.https://forbetterscience.com/2019/11/18/the-teachings-of-chairman-cao/ …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Brian M. Wasko, PhD proslijedio/la je TweetHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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Brian M. Wasko, PhD proslijedio/la je Tweet
Finally, it seems that a change is on the horizon. Cancer-Associated Mutations but No Cancer: Insights into the Early Steps of Carcinogenesis and Implications for Early Cancer Detectionhttps://www.cell.com/trends/cancer/fulltext/S2405-8033(19)30146-3?sf221560070=1#.XawTNMtD5d0.twitter …
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21st-century medicine is defined as targeting biological aging directly, instead of treating individual diseases of aging
#gerosciencehttps://academic.oup.com/ppar/article/29/4/111/5585523 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Brian M. Wasko, PhD proslijedio/la je Tweet
Less than 0.1 percent of federal research dollars being spent on Alzheimer’s disease is being allocated toward the risk factor (biological aging) that accounts for more than 90% of an individual’s risk of developing the disease. https://academic.oup.com/ppar/article/29/4/119/5571541#.XaGAM8HqXyc.twitter …pic.twitter.com/f3q2ZBIQAK
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Brian M. Wasko, PhD proslijedio/la je Tweet
“My advice to young people entering science: you should do it for the love of science … You should enter science because you are fascinated by it” - newly awarded laureate James Peebles speaking at today’s press conference announcing his
#NobelPrize in Physics.pic.twitter.com/JaSM10glQT
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"Lack of knowledge is the true bottleneck to clinical translation. We need to stop telling basic scientists, especially trainees, that their work’s value lies in its translatability"
#nobelprize winner emphasizes the need to support basic science researchhttp://disq.us/t/3i8sdekHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
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