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VirusesImmunity's profile
Prof. Akiko Iwasaki
Prof. Akiko Iwasaki
Prof. Akiko Iwasaki
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@VirusesImmunity

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Prof. Akiko IwasakiVerified account

@VirusesImmunity

We study innate and adaptive immunity to #viruses and #cancer. #COVID19 #immunology #vaccines @HHMINEWS @YaleIBIO @YaleMed @YaleEMD @YaleSPH.

New Haven, CT
medicine.yale.edu/lab/iwasaki/
Joined May 2017

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    Prof. Akiko Iwasaki‏Verified account @VirusesImmunity 1 Jan 2021

    My first tweet of 2021 is going to be about 1 dose vs. 2 dose vaccine. I have tweeted in the past of the immunological advantages of a 2 dose vaccine. However, given the enhanced transmission variants on the rise, we need a modified strategy. (1/n)https://www.theatlantic.com/science/archive/2020/12/virus-mutation-catastrophe/617531/ …

    11:17 AM - 1 Jan 2021
    • 4,164 Retweets
    • 9,579 Likes
    • Jo Brannan Ed Greenaway Taylor Lorenz--- AWAY ON BOOK LEAVE ScuseMeWot Brenda Clery Lorenzo Kimmo Huovilainen Amber Spinella syawal™ シ
    245 replies 4,164 retweets 9,579 likes
      1. New conversation
      2. Prof. Akiko Iwasaki‏Verified account @VirusesImmunity 1 Jan 2021

        Prof. Akiko Iwasaki Retweeted Prof. Akiko Iwasaki

        We typically give vaccines in more than one dose to increase 1) quantity, 2) quality, 3) longevity of antibody responses. This holds true for most vaccines including mRNA vaccines. Here is what I tweeted about this before. (2/n)https://twitter.com/VirusesImmunity/status/1336323024786653187?s=20 …

        Prof. Akiko Iwasaki added,

        Prof. Akiko IwasakiVerified account @VirusesImmunity
        Why do we need a booster shots? This is because B cell responses induced by first dose only generates lower levels, lower affinity and short lived antibody responses. The booster dose(s) allow stimulation of robust long-lasting immunity with high affinity/neutralizing Ab. (end) pic.twitter.com/vOrOnVfuiW
        Show this thread
        20 replies 185 retweets 988 likes
        Show this thread
      3. Prof. Akiko Iwasaki‏Verified account @VirusesImmunity 1 Jan 2021

        However, the 2 dose vaccine with limited number of vaccine means only half the people getting vaccinated at this time. If the virus is spreading slowly, we want to do the right thing and give the most vulnerable 2 doses and others to wait. (3/n)

        9 replies 132 retweets 928 likes
        Show this thread
      4. Prof. Akiko Iwasaki‏Verified account @VirusesImmunity 1 Jan 2021

        Unfortunately, the vaccine roll-out is much slower than we had expected. This means that even the vulnerable have to wait for months to get their 2 shot vaccines. (4/n)https://www.statnews.com/2020/12/29/public-health-experts-grow-frustrated-with-pace-of-covid-19-vaccine-rollout/ …

        8 replies 166 retweets 967 likes
        Show this thread
      5. Prof. Akiko Iwasaki‏Verified account @VirusesImmunity 1 Jan 2021

        Prof. Akiko Iwasaki Retweeted Adam Kucharski

        In the meantime, the virus is mutating and spreading faster. A mutant virus with 50% ⬆️ in transmission kills a lot more people than a mutant with 50% ⬆️ in lethality. A must read thread from @AdamJKucharski 👇🏽 (5/n)https://twitter.com/AdamJKucharski/status/1343567425107881986?s=20 …

        Prof. Akiko Iwasaki added,

        Adam KucharskiVerified account @AdamJKucharski
        Why a SARS-CoV-2 variant that's 50% more transmissible would in general be a much bigger problem than a variant that's 50% more deadly. A short thread... 1/
        Show this thread
        17 replies 401 retweets 1,511 likes
        Show this thread
      6. Prof. Akiko Iwasaki‏Verified account @VirusesImmunity 1 Jan 2021

        So how effective is a single dose vaccine? We do not know for sure, but for at least a month or more, a single shot mRNA vaccines should provide ~90% protection (>14 d post vaccination). This is from the Moderna VRBPAC Briefing Document. (6/n)pic.twitter.com/BuTId1QKGy

        25 replies 266 retweets 1,177 likes
        Show this thread
      7. Prof. Akiko Iwasaki‏Verified account @VirusesImmunity 1 Jan 2021

        Whether a single dose vaccine provide protection from severe COVID is not clear due to small sample size and short follow up duration. (7/n)pic.twitter.com/x0VSOqwSyW

        7 replies 122 retweets 782 likes
        Show this thread
      8. Prof. Akiko Iwasaki‏Verified account @VirusesImmunity 1 Jan 2021

        Prof. Akiko Iwasaki Retweeted Jeffrey Barrett

        I am still a proponent of 2 dose vaccine but given the urgency, we can delay the 2nd dose until more vaccines become available. I know many others have been saying this all along, but it was the B.1.1.7 variant transmission rate that did it for me. (8/n)https://twitter.com/jcbarret/status/1344607063658405888?s=20 …

        Prof. Akiko Iwasaki added,

        Jeffrey Barrett @jcbarret
        Out today: two academic publications (not yet peer reviewed) that formally test whether the new B.1.1.7 variant is more transmissible. Both conclude yes, about 50% more. 🧵
        Show this thread
        28 replies 354 retweets 1,518 likes
        Show this thread
      9. Prof. Akiko Iwasaki‏Verified account @VirusesImmunity 1 Jan 2021

        The good thing about the mRNA vaccine is that if you prime with it, you can boost with other types of vaccines (viral vectored, DNA, mRNA…etc). In the future, a mixed prime boost vaccine strategies can be tested to provide long term protective immunity. (9/n)

        39 replies 254 retweets 1,415 likes
        Show this thread
      10. Prof. Akiko Iwasaki‏Verified account @VirusesImmunity 1 Jan 2021

        So how long can we safely wait in between 1st and 2nd doses? If you look at the childhood vaccine schedules, some boosters are given months to years apart. For COVID vaccine, booster after a few months might be okay. (10/n) https://www.cdc.gov/mmwr/preview/mmwrhtml/rr5102a1.htm …pic.twitter.com/3N3l7L992z

        37 replies 153 retweets 937 likes
        Show this thread
      11. Prof. Akiko Iwasaki‏Verified account @VirusesImmunity 1 Jan 2021

        Prof. Akiko Iwasaki Retweeted Eric Topol

        Well I guess things are already moving along faster than I can type (but @EricTopol types faster than the news) in both UK and US. Posting my thread now before it is completely obsolete (end).https://twitter.com/EricTopol/status/1345080202964029442?s=20 …

        Prof. Akiko Iwasaki added,

        Eric TopolVerified account @EricTopol
        Fauci today: The United States will not use 2nd vaccine dose to vaccinate more people. (via @CNN, @elizcohencnn) That's good because that it's following what we know, the trial data with extraordinary 95% efficacy, avoiding extrapolation and the unknowns.
        84 replies 133 retweets 1,230 likes
        Show this thread
      12. End of conversation

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