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Prikvačeni tweet
I guess people really like seeing cells “syncysh”—a verb I’m making up for the act of forming syncytia. Here’s one of
#NiV env glycoproteins syncysching in ERmCherry-LamininGFP co-transferred Vero cells.#LoveVirology#ViralLeeLab#Nipah https://twitter.com/VirusWhisperer/status/1191895552423800833 …pic.twitter.com/S0QebbRJhcHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Benhur Lee, MD proslijedio/la je Tweet
FYI Coronavirus labs. BioBasic is giving discounted and free rush orders for Coronavirus synthesis. $0.12/base. https://www.biobasic.com/
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Benhur Lee, MD proslijedio/la je Tweet
So far 4 of the 92 Singaporeans on the evacuation flight were infected. What does that say about the prevalence of 2019-nCoV infection in Wuhan?https://www.straitstimes.com/singapore/coronavirus-spore-reports-first-cases-of-local-transmission-4-out-of-6-new-cases-did-not …
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Nice explanatory tweet! Such uncertainty is intrinsic to modeling trends in disease outbreaks when there is so much unknown. If one goes back to numbers predicted ~12days ago to see how numbers match up Feb 4 (~14 days), we should be able to constraint some parameters?
https://twitter.com/richardneher/status/1224692813251534849 …
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HIV drugs used to treat 'small number' of coronavirus patients:
MOH Chief health scientist "these agents appear to be effective . . . They appear promising. I think the trials (in China) will help us understand, whether or not, how effective it will be."https://www.channelnewsasia.com/news/singapore/wuhan-coronavirus-virus-singapore-hiv-drugs-treat-12391030 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Benhur Lee, MD proslijedio/la je Tweet
Fortunately, with my ongoing string of... challenges...
@VirusWhisperer can be confident that the#ViralLeeLab sticks to our ethical guns.#silverlining?Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Benhur Lee, MD proslijedio/la je Tweet
Some discussion about whether
#nCoV2019 will become endemic. It seems that the assumption is that this will mean it becomes less pathogenic with assertion that it is not in the best interest for the virus to kill its host. But it isn't as simple as that...Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Benhur Lee, MD proslijedio/la je Tweet
Have you ever noticed that the Keynote speakers at meetings are always the same people over and over again? How about some innovation and fresh thinking on this, friends? There are lots of mid-career people out there with good ideas and perspective, too.
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Also, to answer questions about whether the elderly appears more prone to develop severe symptoms from
#nCoV2019; here’s a graphic summarizing data from 2 reports in Lancet. They appear to be accurate based on my read of the clinical info provided. Refs are in graphic. 4/4 FIN.pic.twitter.com/LNyIIsqCme
Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
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incentives to develop vaccines and Rx will even be greater; (3) Case Fatality Rate (CFR) for
#nCoV2019 remains consistently at ~2%. I agree this is an OVERestimation due to the majority of asymptomatic/mildly symptomatic infections that are not “confirmed cases”(CC).
2/nPrikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
CAVEAT: any death from an infectious disease (which can always be prevented IN PRINCIPLE) is one too many. Takeaways & my opinions on
@HelenBranswell article:(1)NOT the end of the world even IF#nCoV2019 cannot be contained; (2) IF nCoV2019 becomes endemic like seasonal flu,
1/nhttps://twitter.com/helenbranswell/status/1224721198535389185 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Chioe &Farzan showed years ago that sACE2nn-Ig can potently inhibit SARS/CoVpp entry (ACE2nn is enzymatically inactive and necessary for safety as it will not disrupt delicate balance of renin-angiotensin system). FIN.
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My opinion: No reason why EK-1 peptide or SC-1 peptide against SARS CoV, which is 100% homologous to
#nCoV2019 in RELEVANT target region, cannot be engineered & linked to RBD-Ig or soluble ACE2nn-Ig to make chimeric Abs with
half-life and synergistic potency. 3/n
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BUT both enter cells using “Class I fusion proteins” whose MECHANISTIC conservation can be exploited. (2) Small Receptor Binding Domain (RBD) rather than the entire (large) S1 envelope spike elicits
Neut Titers. Paper by respected authors whom I know personally.
2/nPrikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
#2019n_CoV Peer-reviewed studies now summarized in *Emerg Microb&Infect*:(1)EK-1 peptide is pan-#CoV inhibitor that targets fusion (6-HB formation) in receptor-independent fashion (MECHANISTICALLY analogous to FDA-approved Fuzeon for HIV-1)—HIV has NOTHING to do with CoV— 1/n
https://twitter.com/sciguy999/status/1224697460846669825 …
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Benhur Lee, MD proslijedio/la je Tweet
“The sources that claimed that the coronavirus would infect during the incubation period lack scientific support for this analysis in their articles”https://twitter.com/MackayIM/status/1224542438036889603 …
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Benhur Lee, MD proslijedio/la je Tweet
Great to see several
@UNC_SOM department chairs including@cameronlab and@ReproWoman on this list. Also@UNC_SOM faculty member@Fidera25 and@UNC alumni including@bradylabupenn and@blackscibloghttps://twitter.com/cellmentor/status/1224343451816341504 …
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So important to have visible role models. I’m sure there are more than enough outstanding UnderRepresented in Life Science leaders to have a “top 10” list EVERY month. Please RT
@AcademicChatter#AcademicTwitter#DiversityandInclusion in#STEMhttps://twitter.com/jeanklim/status/1224531391456645120 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
http://APHL.org | https://www.aphl.org/programs/infectious_disease/Pages/Respiratory-Infections.aspx … | has protocols for
#publichealthemergency response & 3 national reference labs for non-flu respiratory infections. Are they being roped in to help@CDCgov where all testing for#2019_nCoV is currently being done?Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Back to my actual job: manuscripts to write, trainees to mentor, Chairman to please, committees to sit on; I'll have to reduce my Tweets. Data/Refs for graphic on
#2019_nCoV#nCoV2019 can be found on http://bit.ly/391hqEn . Latest updates may not reflect most current Info.
https://twitter.com/VirusWhisperer/status/1224279322422403072 …
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