Benhur Lee, MD    

@VirusWhisperer

Viruses are the best cell biologists|Professor-Mentor|🏳️‍🌈Husband|Musings on science & academia| | Views are my own

Manhattan, NY @IcahnMountSinai
Vrijeme pridruživanja: kolovoz 2011.

Tweetovi

Blokirali ste korisnika/cu @VirusWhisperer

Jeste li sigurni da želite vidjeti te tweetove? Time nećete deblokirati korisnika/cu @VirusWhisperer

  1. Prikvačeni tweet

    I guess people really like seeing cells “syncysh”—a verb I’m making up for the act of forming syncytia. Here’s one of env glycoproteins syncysching in ERmCherry-LamininGFP co-transferred Vero cells.

    Poništi
  2. proslijedio/la je Tweet
    prije 15 sati

    FYI Coronavirus labs. BioBasic is giving discounted and free rush orders for Coronavirus synthesis. $0.12/base.

    Poništi
  3. proslijedio/la je Tweet
    prije 4 sata

    So far 4 of the 92 Singaporeans on the evacuation flight were infected. What does that say about the prevalence of 2019-nCoV infection in Wuhan?

    Poništi
  4. Nice explanatory tweet! Such uncertainty is intrinsic to modeling trends in disease outbreaks when there is so much unknown. If one goes back to numbers predicted ~12days ago to see how numbers match up Feb 4 (~14 days), we should be able to constraint some parameters? 🤞

    Poništi
  5. HIV drugs used to treat 'small number' of coronavirus patients: 🇸🇬MOH Chief health scientist "these agents appear to be effective . . . They appear promising. I think the trials (in China) will help us understand, whether or not, how effective it will be."

    Poništi
  6. proslijedio/la je Tweet
    4. velj

    Fortunately, with my ongoing string of... challenges... can be confident that the sticks to our ethical guns. ?

    Prikaži ovu nit
    Poništi
  7. proslijedio/la je Tweet

    Some discussion about whether will become endemic. It seems that the assumption is that this will mean it becomes less pathogenic with assertion that it is not in the best interest for the virus to kill its host. But it isn't as simple as that...

    Prikaži ovu nit
    Poništi
  8. proslijedio/la je Tweet
    prije 19 sati

    Have you ever noticed that the Keynote speakers at meetings are always the same people over and over again? How about some innovation and fresh thinking on this, friends? There are lots of mid-career people out there with good ideas and perspective, too.

    Poništi
  9. Also, to answer questions about whether the elderly appears more prone to develop severe symptoms from ; here’s a graphic summarizing data from 2 reports in Lancet. They appear to be accurate based on my read of the clinical info provided. Refs are in graphic. 4/4 FIN.

    Prikaži ovu nit
    Poništi
  10. CFR=[/]. [] are counted only from severely symptomatic patients that seek treatment, the bottom⬇️ number,i.e.,[] is much larger in reality [# Actual Cases]. SMALL top⬆️ number,i.e.,[]➗by LARGER ⬇️ number [# actual cases]=⬇️⬇️ CFR👇3/n

    Prikaži ovu nit
    Poništi
  11. incentives to develop vaccines and Rx will even be greater; (3) Case Fatality Rate (CFR) for remains consistently at ~2%. I agree this is an OVERestimation due to the majority of asymptomatic/mildly symptomatic infections that are not “confirmed cases”(CC).👇2/n

    Prikaži ovu nit
    Poništi
  12. CAVEAT: any death from an infectious disease (which can always be prevented IN PRINCIPLE) is one too many. Takeaways & my opinions on article:(1)NOT the end of the world even IF cannot be contained; (2) IF nCoV2019 becomes endemic like seasonal flu,👇1/n

    Prikaži ovu nit
    Poništi
  13. Chioe &Farzan showed years ago that sACE2nn-Ig can potently inhibit SARS/CoVpp entry (ACE2nn is enzymatically inactive and necessary for safety as it will not disrupt delicate balance of renin-angiotensin system). FIN.

    Prikaži ovu nit
    Poništi
  14. My opinion: No reason why EK-1 peptide or SC-1 peptide against SARS CoV, which is 100% homologous to in RELEVANT target region, cannot be engineered & linked to RBD-Ig or soluble ACE2nn-Ig to make chimeric Abs with ⬆️half-life and synergistic potency. 3/n 👇

    Prikaži ovu nit
    Poništi
  15. BUT both enter cells using “Class I fusion proteins” whose MECHANISTIC conservation can be exploited. (2) Small Receptor Binding Domain (RBD) rather than the entire (large) S1 envelope spike elicits ⬆️ Neut Titers. Paper by respected authors whom I know personally. 👇2/n

    Prikaži ovu nit
    Poništi
  16. Peer-reviewed studies now summarized in *Emerg Microb&Infect*:(1)EK-1 peptide is pan- inhibitor that targets fusion (6-HB formation) in receptor-independent fashion (MECHANISTICALLY analogous to FDA-approved Fuzeon for HIV-1)—HIV has NOTHING to do with CoV— 1/n 👇

    Prikaži ovu nit
    Poništi
  17. proslijedio/la je Tweet

    “The sources that claimed that the coronavirus would infect during the incubation period lack scientific support for this analysis in their articles”

    Poništi
  18. proslijedio/la je Tweet

    Great to see several department chairs including and on this list. Also faculty member and alumni including and

    Prikaži ovu nit
    Poništi
  19. So important to have visible role models. I’m sure there are more than enough outstanding UnderRepresented in Life Science leaders to have a “top 10” list EVERY month. Please RT in

    Poništi
  20. | | has protocols for response & 3 national reference labs for non-flu respiratory infections. Are they being roped in to help where all testing for is currently being done?

    Poništi
  21. Back to my actual job: manuscripts to write, trainees to mentor, Chairman to please, committees to sit on; I'll have to reduce my Tweets. Data/Refs for graphic on can be found on . Latest updates may not reflect most current Info.☮️✌️

    Poništi

Čini se da učitavanje traje već neko vrijeme.

Twitter je možda preopterećen ili ima kratkotrajnih poteškoća u radu. Pokušajte ponovno ili potražite dodatne informacije u odjeljku Status Twittera.

    Možda bi vam se svidjelo i ovo:

    ·