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VPrasadMDMPH's profile
Vinay Prasad MD MPH
Vinay Prasad MD MPH
Vinay Prasad MD MPH
@VPrasadMDMPH

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Vinay Prasad MD MPH

@VPrasadMDMPH

Charles & Velma Sharp Assc Prof HemeOncDoc @Plenary_Session http://vinayakkprasad.com  http://www.amazon.com/Ending-Medical-Reversal-Improving-Outcomes/dp/1421417723 …

soundcloud.com/plenarysession
Joined February 2013

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    1. Vinay Prasad MD MPH‏ @VPrasadMDMPH 13 Dec 2018

      The history of EBM shows that many of these interventions fail upon rigorous testing. So if you are a proponent of an unproven intervention, how can you avoid the call to test it rigorously?

      1 reply 3 retweets 12 likes
      Show this thread
    2. Vinay Prasad MD MPH‏ @VPrasadMDMPH 13 Dec 2018

      Enter the first @bmj_latest article in 2003 It made the humorous case that no one would ask for an RCT of parachutes Indeed, only a fool would ask for an RCT of an intervention that improves short term mortality from ~100% to ~0%pic.twitter.com/5xUm8OeT8K

      2 replies 6 retweets 23 likes
      Show this thread
    3. Vinay Prasad MD MPH‏ @VPrasadMDMPH 13 Dec 2018

      This was cited 822 times in just over a decade. But the metaphor for medicine was always wrong. Nearly nothing in biomedicine has an ARR of 99% on mortality, most medical practices have modest to marginal effect sizes, where RCTs are vital to separate signal from noise

      1 reply 12 retweets 65 likes
      Show this thread
    4. Vinay Prasad MD MPH‏ @VPrasadMDMPH 13 Dec 2018

      Just consider the IVC filter. We keep seeing non-randomized studies on the topic, but this is because the device is on the market lacking any proper testing; So how can u avoid testing it? Hail it as a parachute? Who can say otherwise

      3 replies 4 retweets 20 likes
      Show this thread
    5. Vinay Prasad MD MPH‏ @VPrasadMDMPH 13 Dec 2018

      In 2016, Michael Hayes & I asked how many biomedical practices were really parachutes. We traced the citation record of the 2003 BMJ paper and found that it was nearly nothing in medicine https://www.ncbi.nlm.nih.gov/pubmed/29343497 pic.twitter.com/4pZbgtYFKI

      2 replies 18 retweets 50 likes
      Show this thread
    6. Vinay Prasad MD MPH‏ @VPrasadMDMPH 13 Dec 2018

      Enter the new paper. It suggests that you could perform an RCT of a parachute if you distort the trial design to a trivial hypothesis/ question.pic.twitter.com/cwOLmiR4N4

      3 replies 5 retweets 17 likes
      Show this thread
    7. Vinay Prasad MD MPH‏ @VPrasadMDMPH 13 Dec 2018

      Vinay Prasad MD MPH Retweeted Vinay Prasad MD MPH

      continued herehttps://twitter.com/VPplenarysesh/status/1073298773634252800 …

      Vinay Prasad MD MPH added,

      Vinay Prasad MD MPH @VPrasadMDMPH
      Obviously, the metaphor is that this is what happened with COURAGE and ASTRAL and CORAL-- these trials were only negative because no one had the guts to test people with serious malady. But, that analogy would be wrong
      Show this thread
      1 reply 4 retweets 8 likes
      Show this thread
    8. Vinay Prasad MD MPH‏ @VPrasadMDMPH 13 Dec 2018

      Obviously, the metaphor is that this is what happened with COURAGE and ASTRAL and CORAL-- these trials were only negative because no one had the guts to test people with serious malady. But, that analogy would be wrong

      1 reply 1 retweet 8 likes
      Show this thread
    9. Vinay Prasad MD MPH‏ @VPrasadMDMPH 13 Dec 2018

      In biomedicine it is essential to prove that an intervention works under some circumstances. And nothing stops proponents of renal artery stenting or stenting chronic stable angina from doing just that, even 1 time, in any setting

      1 reply 4 retweets 12 likes
      Show this thread
    10. Vinay Prasad MD MPH‏ @VPrasadMDMPH 13 Dec 2018

      Even the pharma companies who I give such a lashing to in @Plenary_Session for running bad trials, are better than many proponents of devices and interventions because they at least show this under *some* circumstances.

      1 reply 5 retweets 17 likes
      Show this thread
      Vinay Prasad MD MPH‏ @VPrasadMDMPH 13 Dec 2018

      So, I think this rejoinder to the @bmj_latest will be misused for another decade and perpetuate the mentality of no need to test what works because we already know it (original paper) and supplement it with...

      11:34 AM - 13 Dec 2018
      • 5 Retweets
      • 15 Likes
      • Harlan Krumholz WonkaWasInnocent Nobody Sarah Price Hancock, MS, CRC Lionel Messy Kevin Marc Casañas Escarré Mike Rose Sören Sievers
      2 replies 5 retweets 15 likes
        1. New conversation
        2. Vinay Prasad MD MPH‏ @VPrasadMDMPH 13 Dec 2018

          when trials are negative of things we think work (this paper) that must be because they *excluded sickest pts *trivialized the question *insert favorite objection

          1 reply 3 retweets 16 likes
          Show this thread
        3. Vinay Prasad MD MPH‏ @VPrasadMDMPH 13 Dec 2018

          I wonder if the @bmj_latest --- the premiere guardian of EBM -- recognizes that they are undermining their own cause. Oh well, all I can do is make a podcast! @Plenary_Session

          2 replies 3 retweets 34 likes
          Show this thread
        4. Vinay Prasad MD MPH‏ @VPrasadMDMPH 13 Dec 2018

          Vinay Prasad MD MPH Retweeted Ajay Kirtane MD SM

          Check it out. Already being used the way i suggestedhttps://twitter.com/ajaykirtane/status/1073278344731475969?s=20 …

          Vinay Prasad MD MPH added,

          Ajay Kirtane MD SM @ajaykirtane
          Brilliantly done and too bad it wasn't (at least directly) about PCI otherwise it would have made the @nytimes 🤣 https://twitter.com/rwyeh/status/1073267912037814273 …
          2 replies 2 retweets 11 likes
          Show this thread
        5. Vinay Prasad MD MPH‏ @VPrasadMDMPH 18 Dec 2018

          On this episode of @Plenary_Session I flesh out this discussion even morehttps://soundcloud.com/plenarysession/129-rct-of-parachutes-and-frameworks-for-internal-medicine-with-dr-andre-mansoor …

          2 replies 2 retweets 3 likes
          Show this thread
        6. End of conversation
        1. Kevin Schwartz‏ @DrKevinSchwartz 15 Dec 2018
          Replying to @VPrasadMDMPH @bmj_latest

          My take away from this is not that these authors are suggesting we should not be testing interventions because we think they already work, but that these pre-existing biases can distort the trial. I agree with you that it’s important people do not interpret it in this way

          0 replies 0 retweets 0 likes
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