Fyodor Urnov

@UrnovFyodor

Gene editor + Professor + Director + Beatles fan =

Berkeley, CA
innovativegenomics.org
Vrijeme pridruživanja: studeni 2018.
67 fotografija ili videozapisa Fotografije i videozapisi

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  1. 28. sij

    TFW you have a key file opened locally, the rest of the team then uploads 12 hrs of work on it to the cloud, and your local file overwrites that. You buy a one-way ticket for yourself to the bottom of the Marian Trench ... and then you find that box keeps the previous versions.

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  2. 23. sij

    Hear! Hear!! (At this point, plain vanilla editing in workhorse settings is about as hard as PCR of a nonrepetitive region on purified genomic DNA - of note, most papers are not called "PCR-enabled Discovery of ABC1-driven DEF2 Infatuation in Primary Human Mellotons")

    Those of us who work on gene editing would appreciate it if you’d stop including “CRISPR” in your abstracts and paper titles unless it’s absolutely key to the work. Tired of sifting through millions of pub alerts that just say “we created a mouse line w CRISPR.”
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  3. 22. sij

    Don't laugh. The baristas who make best US espresso I have ever had - Espresso Vivace in Seattle (David Schomer) - obsesses precisely over these parameters.

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  4. 22. sij

    Parrot sketch: Cleese: [complains] Jones: I don't have to do this! I am a qualified brain surgeon!! Cleese [breaks 4th wall]: Sorry, but this is irrelevant. Jones (with flawless timing): I know, but it's hard to drag these out to 30 min! will forever be missed.

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  5. 21. sij

    I feel awkward pointing myself out in such an august lineup, but FWIW, my talk here is on the "next generation of edited humans" that I have often been asked to give and put online. Et voila!

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  6. 21. sij

    I highly recommend watching all the talks for a 2020-grade, reality-based perspective on what the Age of Editing can bring us (BOTH Jennifer Doudna and Peter Marks spoke - it was that kind of meeting!). Who needs Netflix when there is NASflix?

    Chicken pecking corn
    Last month, we hosted Life 2.0: The Challenge and Promise of a CRISPR Path to a Sustainable Planet with . Now, you can watch the talks on gene drives, editing farm animals, environmental concerns in editing, germline editing, and more!
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  7. 21. sij

    Teaching classics Spring 2020. :-)

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  8. 19. sij

    A nonscience request for help. I want to introduce my 3.5 yo to the Muppet Show. It emerged that this ABC thing is an evil impersonator. Where do the Henson Muppets live on the interwebs? Eg where is the full-length show isoform of this Bullock gem?

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  9. 18. sij

    . - would very much appreciate your take on this.

    Pleased to report ’s manuscript on biases in CRISPR fitness screens is now available on at . Key points: ~20% FNR, lower expression -> lower replicablity, and half of all constitutively expressed genes are *never* essential!
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  10. 14. sij

    [2/2] "Well you may think the world's black and white And you're dirty or you're clean You better watch out you don't slip Through them spaces in between" "Cross My Heart" - Bruce Springsteen

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  11. 14. sij

    [1/2] Nature is a set of gradients (see part 2), and CRISPRi/a - a way to mimic that, and control it. Very stylish and impactful work. H/t [disclosure - I collaborate with Jonathan on an unrelated project]

    Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs
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  12. 13. sij

    Carl Pabo discovered how zinc fingers bind to DNA, and then trained the scientists who designed all the ZFNs in current clinical trials. After enabling editing, he turned to even bigger challenges (see below). Carl is the deepest thinker I have ever met.

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  13. 12. sij

    As ca. 1,000 Russian pedants, such as myself, have doubtless pointed out by now, the poem is by Apollon Maikov, not my illustrious namesake Dostoyevsky, but Ariel - ignore them and myself. Your article is wonderful and the quote is apt.

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  14. 12. sij

    [1/2] This superb piece by describes a person who bears a mutation in one of several targets for gene editing in intractable pain. Like with BCL11A and sickle cell disease, human genetics uncovers editing-based approaches to disease.

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  15. 11. sij

    A DEEPLY affecting article. Scientifically, magnificent to see Stu Orkin, who led the discovery of the BCL11A enhancer, recognized for work that gave us 3 trials for SCD: this one and the and editing ones.

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  16. 9. sij

    Sir Aaron's discovery of the zinc finger and invention of methods to engineer two-finger modules took editing from PoC to clinical trials running today. In his mid-80s (when I worked with him) his was the sharpest mind in any room. ht

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  17. 8. sij

    Fellow intranuclear people - I encourage you to look at extended data fig 7a (effect on transcription) and the first para on page 3. So much for us understanding what CTCF does, despite 1,910 papers about it. Also yay editing as tool to do definitive expts

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  18. 7. sij

    This new legislation is EXACTLY right for the Age of Editing when rare mutations are clinically actionable.

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  19. 3. sij

    [3/3] ... and a masterpiece by Paul McCartney, with Alan Civil's original, and sublime French horn solo - George Martin's idea.

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  20. 3. sij

    [2/3] ... and a masterpiece by Paul McCartney and him.

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