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Tuliodna's profile
Tulio de Oliveira
Tulio de Oliveira
Tulio de Oliveira
@Tuliodna

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Tulio de Oliveira

@Tuliodna

Director of CERI: Centre for Epidemic Response & innovation, South Africa @StellenboschUni @krisp_news @UKZN @DrPatSoonShi @RockefellerFdn

Stellenbosch & Durban, SA
ceri.africa
Joined November 2011

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    1. Tulio de Oliveira‏ @Tuliodna 3 Jun 2021

      In this online pre-print, we present a case of persistent SARS-CoV-2 infection with accelerated intra-host evolution in a patient with advanced HIV and antiretroviral treatment failure in South Africa. Paper deposited at medRxiv &available at: https://www.krisp.org.za/publications.php?pubid=336 … @sigallab

      16 replies 155 retweets 276 likes
      Show this thread
    2. Tulio de Oliveira‏ @Tuliodna 3 Jun 2021

      SARS-CoV-2 RT-PCR was positive for 216 days (27 weeks). At all time-points between day 0 and day 216 there was a mean Ct ranging from 16.4 to 31.6. The patient had HIV drug resistance and was not responding to therapy.pic.twitter.com/CCFxg81WAV

      2 replies 12 retweets 37 likes
      Show this thread
      Tulio de Oliveira‏ @Tuliodna 3 Jun 2021

      Over 30 mutations accumulated over time, many of them changing aminoacids that are common of variants of concern.pic.twitter.com/WX4hR2AMOR

      3:40 AM - 3 Jun 2021
      • 23 Retweets
      • 48 Likes
      • lixingguang Astronaut MD in PAPR Mel 🌈✨🏳️‍🌈 Alexandre Freitas సిరా.. #CancerDoc AjayMehta MD Proud European from Austria🇪🇺🇦🇹 🌏 Prof.S.Venugopalan🇮🇳 Jeep
      2 replies 23 retweets 48 likes
        1. New conversation
        2. Tulio de Oliveira‏ @Tuliodna 3 Jun 2021

          At day 6, the E484K substitution in the receptor-binding domain (RBD) emerged, along with a substitution in the S2 subunit (A1078V). The E484K mutation remained in the consensus sequence until day 34, but then persisted at low frequency up to day 190

          1 reply 9 retweets 32 likes
          Show this thread
        3. Tulio de Oliveira‏ @Tuliodna 3 Jun 2021

          At the later time points, there was a significant shift in the virus population, with the emergence at day 71 of the K417T and F490S mutations in the spike RBD, followed by the emergence of L455F and F456L at day 106. At day 190, there was the emergence of D427Y and N501Y.

          1 reply 5 retweets 23 likes
          Show this thread
        4. Tulio de Oliveira‏ @Tuliodna 3 Jun 2021

          Table of mutations in the Spike protein, including the appearance of 501Y, 484K and 417T (all from variants of concern) and mutations and deletion at the N-terminal domain (NTD)pic.twitter.com/cyqbn3QcVa

          1 reply 7 retweets 20 likes
          Show this thread
        5. Tulio de Oliveira‏ @Tuliodna 3 Jun 2021

          All genomes fell within PANGO lineage B.1.1.2732, a South African lineage that was previously part of B.1.1.56, one of the most prevalent lineages in the first wave of the epidemic in the province of KwaZulu-Natal in South Africa.pic.twitter.com/ie1O0tiHa4

          1 reply 3 retweets 20 likes
          Show this thread
        6. Tulio de Oliveira‏ @Tuliodna 3 Jun 2021

          There were the appearance of mutations also in the N protein and ORF1apic.twitter.com/w2LGxuNvJP

          3 replies 3 retweets 18 likes
          Show this thread
        7. Tulio de Oliveira‏ @Tuliodna 3 Jun 2021

          Discussion: Despite a short clinical illness of moderate severity, SARS-CoV-2 PCR positivity persisted up to 216 days. We demonstrate significant shifts in the virus population over that time, involving multiple mutations at key neutralizing antibody sites in the spike RBD & NTD

          1 reply 10 retweets 28 likes
          Show this thread
        8. Tulio de Oliveira‏ @Tuliodna 3 Jun 2021

          Most other cases of persistent infection have been described in people with haematological malignancies or people receiving immunosuppressive therapies for solid organ transplants or other chronic medical conditions

          1 reply 4 retweets 21 likes
          Show this thread
        9. Tulio de Oliveira‏ @Tuliodna 3 Jun 2021

          There is one other documented case of prolonged infection in a person with HIV - in that case the person was ART-naïve with profound immunosuppression and genome sequencing revealed only a single emergent mutation in spike (T719I) at day 53

          1 reply 5 retweets 20 likes
          Show this thread
        10. Tulio de Oliveira‏ @Tuliodna 3 Jun 2021

          The genomic and clinical data suggest that virus evolution may have been driven by selective pressure from an impaired neutralizing antibody response due to advanced HIV disease.

          1 reply 9 retweets 32 likes
          Show this thread
        11. Tulio de Oliveira‏ @Tuliodna 3 Jun 2021

          Disruptions to HIV programs as a result of COVID-19 could potentially increase the burden of advanced HIV45. These findings highlight the importance of maintaining essential health services in high HIV prevalence settings, and accelerating progress towards 90-90-90 targets.

          2 replies 14 retweets 40 likes
          Show this thread
        12. Tulio de Oliveira‏ @Tuliodna 3 Jun 2021

          If persistent SARS-CoV-2 infection and evolution of virus does occur more frequently in the context of HIV, it may provide justification for prioritising people living with HIV for COVID-19 vaccination.

          6 replies 15 retweets 57 likes
          Show this thread
        13. Tulio de Oliveira‏ @Tuliodna 3 Jun 2021

          Real teamwork with @farinakarim @sigallab @rjlessells @AHRI_News @krisp_news and the clinical team of the Infectious Diseases Department of UKZN!

          6 replies 1 retweet 39 likes
          Show this thread
        14. End of conversation

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