Hm. IME, mostly just trauma/frozen emotionality. And being surrounded by noise and assholes.
You get that out of the way, and the whole world opens up.
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<3 sorry for misunderstanding. Yeah pain receptors are a pain. The body sure likes producing pain.
Alchemical transformation is a bit above my pay grade still.
It seems like the base pain sensations themselves can be befriended, but no idea how physiological aspects of it work.
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I would really like to know how to do some deep hormonal transformations to get rid of some forms of agony, but I haven't seen any exoteric science for more than the simplest stuff, and who knows what of the esoteric stuff is time-wasting BS or even harmful?