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Our paper examining the utility of
#polygenicscores for purposes of embryo screening for quantitative traits is out in Cell today. https://www.cell.com/cell/fulltext/S0092-8674(19)31210-3 … See explainer by my colleague@ShaiCarmi below:https://twitter.com/ShaiCarmi/status/1197556022367252481 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Congratulations, Max, on a tremendous effort that yielded critical new insights!https://twitter.com/maxzylam/status/1196465231507144704 …
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Todd Lencz proslijedio/la je Tweet
Thanks to coauthors (
@ToddLencz@akmalhotramd, among others not on Twitter) and reviewers.Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Todd Lencz proslijedio/la je Tweet
With respect to choosing IMPORTANT TOPICS - I would advocate that the genetics of mental disorders and cognitive traits rank top on my list. We need to build capacity in brain sciences and we need the best and brightest to join us in this important work.

https://twitter.com/skathire/status/1192429587235520512 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
CLiP is well powered for highly polygenic GWAS traits, detecting heterogeneity in PGC schizophrenia cohorts (from the 2014 Nature paper) across SNPs totaling 3.4% of variance explained. 6/6
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Aside from generating insights into disease etiology, CLiP can also be used to evaluate polygenic risk scores when heterogeneity is undesirable, such as for transferability across demographic groups.
#PRS 5/6Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
We also develop extensions of CLiP to handle quantitative predictors (such as gene expression) and quantitative phenotypes. 4/6
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CLiP takes advantage of expected correlations between associated SNPs when ascertaining for cases. These correlations are expected of all logistic and liability threshold models, but in heterogeneous cohorts they are altered. 3/6
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We developed a novel method called CLiP (Correlated Liability Predictors). CLiP calculates a Z-score testing for heterogeneity in case/control phenotypes. Requirements are only genotype and phenotype data and summary statistics for a single trait. 2/6
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Pleased to announce new work posted to biorxiv led by my colleagues
@itsikp and Jie Yuan@ColumbiaCompSci It is often assumed that complex disorder (like schizophrenia) are heterogeneous. Here, we utilize GWAS data to identify heterogeneity within a complex phenotype.#PRS 1/6https://twitter.com/biorxiv_bioinfo/status/1190343125564305408 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Todd Lencz proslijedio/la je Tweet
We are very excited that one of our papers, led by Dr Gail Davies, is fourth in the 'most read' Top 50 Life and Biological Sciences papers in 'Nature Communications'. You can find it here: https://edin.ac/2pV2BlG Or browse the list here: http://edin.ac/32ZOvNZ pic.twitter.com/bkepi1O5DO
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Todd Lencz proslijedio/la je Tweet
RSVP for 10/21 inaugural Neuropsychiatric Disease Working Group Evening Lecture feat. Kristen Brennand/
@IcahnMountSinai,@ToddLencz/@NorthwellHealth,@GogosLabZMBBI & Stavros Lomvardas/@Columbia. Moderator: NYGC Scientific Director & CEO Tom Maniatis, PhD http://bit.ly/2Mve2rN pic.twitter.com/oBnZ2Zw2Wb
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Todd Lencz proslijedio/la je Tweet
The Feinstein Institutes' Kevin Tracey weighs in on recent
#opioid settlements in his latest op-ed with@CNNBusiness.https://www.cnn.com/2019/09/30/perspectives/opioid-epidemic-purdue-pharma-settlement/index.html …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Todd Lencz proslijedio/la je Tweet
#icdabio2019@dalygene on ability of isolated pops to find new genetic associations to rare+common disease: if one isolated European pop can provide this much content, imagine how much we’re missing by not focusing other diverse and isolated pops around the world.@VariantBiopic.twitter.com/iO621o6yKq
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Todd Lencz proslijedio/la je Tweet
New
#GWAS preprint from the@VAResearch#MillionVeteranProgram.#opioid dependence is associated with#OPRM1 risk allele in >80k veterans. Genetic correlation with#mentalhealth,#smoking, and#alcoholism. Great work from@hangzhou202 et al.#opioidcrisishttps://www.medrxiv.org/content/10.1101/19007039v1 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
that's a name you don't want to hear
@akmalhotramdhttps://twitter.com/CBSSportsMLB/status/1162848824311930880 …
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Todd Lencz proslijedio/la je Tweet
Weight gain is severe side effect of antipsychotic treatment. Work from
@philipphoman@miklosargyelan@toddlencz@akmalhotramd shows in early-phase psychosis patients, structure and function of human striatum associated with antipsychotic weight gainhttps://www.nature.com/articles/s41386-019-0464-y …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Todd Lencz proslijedio/la je Tweet
Psychiatric Genetics Researchers! We are inviting you to participate on a Survey about Return of Results (NIH R00HG008689). If you have not received an email with a survey link but would like to participate please DM with your email.
@ISPGnet@PGCgeneticsHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
pleiotropic analysis is the next wave of high-impact GWAShttps://twitter.com/williamreay96/status/1158516893776408576 …
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Our paper demonstrating that cognitive genomics can be used to differentiate biological pathways contributing to risk for schizophrenia is now out in the American Journal of Human Genetics. Here is a free link, and an explainer is embedded below: https://urldefense.proofpoint.com/v2/url?u=https-3A__authors.elsevier.com_a_1ZUgA-5F4GsVE9z&d=DwMFaQ&c=vq5m7Kktb9l80A_wDJ5D-g&r=LTw8215LRLXzOTD6vjTzDRqorsQozAAjYS7FpCig_0o&m=-Ieqz08yZv6-qiIH3eGuwMQCyTUmJDPZrewVrnsWGNs&s=tCVnyhXNysuAzYbsEEDafU_ob8gsZEKWDbc8SwDwSEA&e= …https://twitter.com/ToddLencz/status/1087365148849946624 …
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