Tin-Long Yiu

@TinLong_Yiu

Neuroscience PhD student . Interested in understanding how cerebellar computation is influenced by neuromodulation during sensorimotor learning.

Portland, OR
Vrijeme pridruživanja: veljača 2018.

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    Cerebellum-specific deletion of the GABAA receptor δ subunit alters anxiety-like, social and maternal behaviors without affecting ...

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  2. proslijedio/la je Tweet
    25. pro 2019.

    1/n Motor cortex controls the arm by sending neural activity patterns to the spinal cord and brainstem. But how are these patterns generated? We study this question in our new paper in , with J-Z Guo, J Cohen, M Mischiati, , et al.

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    20. pro 2019.

    New research in shows that Purkinje cells have the ability to modulate & filter incoming signals, providing new insights into the learning mechanisms of the cerebellum & brain. A new learning mechanism at the dendritic level:

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    Cerebellar dopamine D2 receptors regulate preference for social novelty

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  5. proslijedio/la je Tweet
    15. pro 2019.

    This started as a side project. We recorded from cerebellar molecular layer interneurons (MLIs) because we were deploying one of our 2P miniature microscopes to Isabel Llano's lab. We found that MLIs encode for valence of the stimulus!

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    Cerebellar-recipient motor thalamus drives behavioral context-specific movement initiation

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    Genetically encoded voltage indicator Archon_Kv2.1 now published for in vivo examination of subthreshold voltage changes from

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    9. lis 2019.

    Congrats Shinichiro!! Modular organization of cerebellar climbing fiber inputs during goal-directed behavior | eLife

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    7. lis 2019.

    Our most recent work on “computation-through-dynamics.” We propose that cognitive control can be understood in terms of principles of motor control: 1) control, 2) simulation, and 3) estimation. Many thanks to , CJ Chang, Evan Remington

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    25. ruj 2019.

    Our new preprint is now up! Online decoding of arm reach direction using 2P calcium imaging in NHP with , Xulu Sun, , . , , Maneesh Sahani, Eyal Seidemann, and many others. 1/10

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    NeuroTwitter, my lab's latest! The cerebellum is necessary for evidence accumulation in working memory, and helps to stabilize stored information! A groundbreaking paper by Ben Deverett on a cognitive role for the cerebellum. In Nature Communications:

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    14. svi 2019.

    1/n In 1573, Varolio described the pontine nuclei (PN), which link cerebral cortex to cerebellum. Today, however, little is known about their function. We study their contribution to dexterity in the latest lab preprint: .

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    9. svi 2019.

    New paper is out today in ! New faster, sensitive and multicolor genetically encoded calcium indicator: Thanks to a great team, especially Atsuya Takeuchi, Satoshi Manita , and Haruhiko Bito!

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  14. 4. svi 2019.

    Cerebellar Purkinje cells control eye movements with a rapid rate code that is invariant to spike irregularity

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    Our paper showing that reward signals are delivered to the cerebellum by the most powerful synapse in the brain, the climbing fiber - Purkinje cell connection, is out today in . Great work by , and .

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  16. proslijedio/la je Tweet
    2. tra 2019.

    Sharing a Matlab toolkit for working with Neuropixel datasets and Kilosort2 sorts. Similar to cortex-lab's spikes repo, designed for careful preprocessing of SpikeGLX datasets without manually handling metadata. Documentation at

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    Pioneering neuroscientist and founding director of the RIKEN Brain Science Institute, Dr. Masao Ito, passed away on Dec. 18. 伊藤正男先生 逝去のお知らせ

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  18. 11. tra 2018.

    The basal ganglia and the cerebellum: nodes in an integrated network

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  19. 31. ožu 2018.

    Daniel Wolpert, Cambridge: Probabilistic models of sensorimotor control via

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    Neuroprosthetic rehabilitation restores motor recovery in rats by rerouting cortical commands through residual reticulospinal pathways.

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