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TeubenRoald's profile
Roald Teuben
Roald Teuben
Roald Teuben
@TeubenRoald

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Roald Teuben

@TeubenRoald

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Baltimore, MD
Joined July 2017

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    1. J.D. Haltigan‏ @JDHaltigan Sep 14
      Replying to @KirkegaardEmil

      diphenhydramine will do just fine.

      1 reply 0 retweets 0 likes
    2. Roald Teuben‏ @TeubenRoald Sep 15
      Replying to @JDHaltigan @KirkegaardEmil

      Diphenhydramine and some other anticholinergics have been linked to cognitive decline and dementia. Pretty conclusive that risk increases with use for people over 65. Don't make it a habit 😉

      1 reply 0 retweets 1 like
    3. J.D. Haltigan‏ @JDHaltigan Sep 15
      Replying to @TeubenRoald @KirkegaardEmil

      I had heard about this...do you have a link to a relevant meta?

      1 reply 0 retweets 0 likes
    4. Roald Teuben‏ @TeubenRoald Sep 15
      Replying to @JDHaltigan @KirkegaardEmil

      I can't find a meta-analysis. Cohort studies by Gray 2015 and Richardson 2018 raised the biggest alarm lately.

      1 reply 0 retweets 0 likes
    5. J.D. Haltigan‏ @JDHaltigan Sep 15
      Replying to @TeubenRoald @KirkegaardEmil

      link to studies at all?

      1 reply 0 retweets 0 likes
    6. Roald Teuben‏ @TeubenRoald Sep 15
      Replying to @JDHaltigan @KirkegaardEmil

      https://youtu.be/VbK0qQ04tak  Gray 2015 https://www.ncbi.nlm.nih.gov/m/pubmed/25621434/ … Richardson 2018 https://www.bmj.com/content/361/bmj.k1315 …

      1 reply 0 retweets 1 like
    7. J.D. Haltigan‏ @JDHaltigan Sep 15
      Replying to @TeubenRoald @KirkegaardEmil

      Would be hard to draw any firm conclusions about diphenhydramine alone from these studies...aside from caution as with any other drug.

      1 reply 0 retweets 1 like
    8. Roald Teuben‏ @TeubenRoald Sep 16
      Replying to @JDHaltigan @KirkegaardEmil

      Fun fact: a massive acute dose of diphenhydramine (very bad idea, say 500mg+) will obliterate short-term memory for the duration. Someone on the street might mistake the delirious case for an alzheimer's patient...

      3 replies 0 retweets 0 likes
    9. Roald Teuben‏ @TeubenRoald Sep 16
      Replying to @TeubenRoald @JDHaltigan @KirkegaardEmil

      Gotta wonder if there's minor cognitive hit from taking diphenhydramine regularly. Like grandma taking it every night. And I suppose when you're old, cognitive decline has sort of positive feedback b/c it can lower quality of life.

      1 reply 0 retweets 0 likes
    10. J.D. Haltigan‏ @JDHaltigan Sep 16
      Replying to @TeubenRoald @KirkegaardEmil

      What’s the propsed mechanistic explanation in your view? I could see a downregulation at the receptor maybe impacting certain domains of cognition but not others. But parsing this from a host of other plausible factors into a causal role would be most difficult I would think.

      1 reply 0 retweets 0 likes
      Roald Teuben‏ @TeubenRoald Sep 16
      Replying to @JDHaltigan @KirkegaardEmil

      I don't know what a good pharmacological mechanism is, I should reread the discussion in those papers. It's just uncanny that a high-dose anticholinergic like benadryl mimics dementia. Lot of crazy "trip reports" of people doing this recreationally!

      7:39 PM - 16 Sep 2018
      1 reply 0 retweets 0 likes
        1. New conversation
        2. J.D. Haltigan‏ @JDHaltigan Sep 16
          Replying to @TeubenRoald @KirkegaardEmil

          Right but acute, transient effects different than structural brain deficits in dementia I would surmise. The whole point of Benadryl to act transiently lol. Tho not a dementia expert by any means...

          1 reply 0 retweets 0 likes
        3. Roald Teuben‏ @TeubenRoald Sep 16
          Replying to @JDHaltigan @KirkegaardEmil

          I agree. Wouldn't want to base an argument on the acute effect of a massive dose.

          1 reply 0 retweets 0 likes
        4. J.D. Haltigan‏ @JDHaltigan Sep 16
          Replying to @TeubenRoald @KirkegaardEmil

          speaking of diphenhydramine, what is the active agent in prescription sleep aids like Ambien et al.? Another antihistamine? + relaxant?

          1 reply 0 retweets 0 likes
        5. Roald Teuben‏ @TeubenRoald Sep 16
          Replying to @JDHaltigan @KirkegaardEmil

          Ambien, Lunesta, Sonata are "z-drugs" related to benzodiazepines & act on GABA -- different mechanism from anticholinergic drowsiness like benadryl. Here is a good rundown on drug classes of sleep aids. (Aside from the conjecture about links to dementia)https://mentalhealthdaily.com/2015/02/20/dementia-linked-to-benzodiazepines-sleeping-pills-anticholinergics/ …

          1 reply 0 retweets 0 likes
        6. J.D. Haltigan‏ @JDHaltigan Sep 16
          Replying to @TeubenRoald @KirkegaardEmil

          Most definitely would treat all of this tentatively. For the average person perhaps more meaningful (i.e., in the aggregate), but like anything else, if you are taking anything repeatedly and live a certain lifestyle...and that's not even considering G effex.

          0 replies 0 retweets 0 likes
        7. End of conversation

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