Melatonin for ... life extension? By the looks of it, looks like only younger people can sleep properly. https://www.ncbi.nlm.nih.gov/pubmed/21451205 pic.twitter.com/ipifUgQqEr
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Gotta wonder if there's minor cognitive hit from taking diphenhydramine regularly. Like grandma taking it every night. And I suppose when you're old, cognitive decline has sort of positive feedback b/c it can lower quality of life.
What’s the propsed mechanistic explanation in your view? I could see a downregulation at the receptor maybe impacting certain domains of cognition but not others. But parsing this from a host of other plausible factors into a causal role would be most difficult I would think.
I don't know what a good pharmacological mechanism is, I should reread the discussion in those papers. It's just uncanny that a high-dose anticholinergic like benadryl mimics dementia. Lot of crazy "trip reports" of people doing this recreationally!
Right but acute, transient effects different than structural brain deficits in dementia I would surmise. The whole point of Benadryl to act transiently lol. Tho not a dementia expert by any means...
I agree. Wouldn't want to base an argument on the acute effect of a massive dose.
speaking of diphenhydramine, what is the active agent in prescription sleep aids like Ambien et al.? Another antihistamine? + relaxant?
Ambien, Lunesta, Sonata are "z-drugs" related to benzodiazepines & act on GABA -- different mechanism from anticholinergic drowsiness like benadryl. Here is a good rundown on drug classes of sleep aids. (Aside from the conjecture about links to dementia)https://mentalhealthdaily.com/2015/02/20/dementia-linked-to-benzodiazepines-sleeping-pills-anticholinergics/ …
Most definitely would treat all of this tentatively. For the average person perhaps more meaningful (i.e., in the aggregate), but like anything else, if you are taking anything repeatedly and live a certain lifestyle...and that's not even considering G effex.
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