Melatonin for ... life extension? By the looks of it, looks like only younger people can sleep properly. https://www.ncbi.nlm.nih.gov/pubmed/21451205 pic.twitter.com/ipifUgQqEr
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I had heard about this...do you have a link to a relevant meta?
I can't find a meta-analysis. Cohort studies by Gray 2015 and Richardson 2018 raised the biggest alarm lately.
link to studies at all?
Would be hard to draw any firm conclusions about diphenhydramine alone from these studies...aside from caution as with any other drug.
Fun fact: a massive acute dose of diphenhydramine (very bad idea, say 500mg+) will obliterate short-term memory for the duration. Someone on the street might mistake the delirious case for an alzheimer's patient...
Gotta wonder if there's minor cognitive hit from taking diphenhydramine regularly. Like grandma taking it every night. And I suppose when you're old, cognitive decline has sort of positive feedback b/c it can lower quality of life.
What’s the propsed mechanistic explanation in your view? I could see a downregulation at the receptor maybe impacting certain domains of cognition but not others. But parsing this from a host of other plausible factors into a causal role would be most difficult I would think.
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