You can give a mouse a stroke which wrecks its motor skills, and start re-training the next day (and so on) until a full recovery. But if you wait a week after the stroke to re-train it, it NEVER fully recovers.
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Perhaps there's an analogy between this and psychedelics in therapy. PTSD and chronic anxiety can be deeply ingrained, but psilocybin and MDMA (w/ the right setting) have proven their power in making the mind/brain plastic enough to allow long-lasting corrective changes.
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