First is that all these measurements were clearly labeled "exploratory" and pre-registered as such. Yay!https://clinicaltrials.gov/ct2/show/NCT00427193 …
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But it got me to look at the earlier paper, which reported weight loss and change in resting metabolism. Remarkably, subjects maintained a loss of 10% of body weight over 2 years. This is WAY better than most diet results. https://academic.oup.com/biomedgerontology/article/70/9/1097/2949096 …pic.twitter.com/dbklAJ1y0F
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OK! That's pretty good. And researchers also measured resting metabolism. This is key, since your body tries to hang on to the weight you're trying to lose by lowering your resting metabolism. See
@KevinH_PhD's work on Biggest Loser participants: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989512/ …pic.twitter.com/llMCRRF13R
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Metabolic rate of course goes down when you lose weight because your body is smaller and needs less energy. But the crucial question is whether it goes down MORE than the weight loss would predict. And it does. But not much, in this case.pic.twitter.com/szYeW7PlaS
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After losing 10% of body weight, metabolism was about 40 calories/day lower than the model predicted, compared to about 20 for the control group. And it's not the first to show a relatively small metabolic penalty.https://www.washingtonpost.com/news/wonk/wp/2016/05/05/why-the-weight-loss-study-everyone-has-been-sharing-is-kind-of-misleading/ …
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So, lessons from CALERIE: - Cutting calories, rather than focusing on macronutrients, can be a successful weight loss strategy. - The metabolic penalty that is a big factor in weight regain is often quite small - Three cheers for pre-registration! OK I'm done now.
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Am I reading this correctly that losing 10% of bodyweight resulted in only about -9 mg/dL in LDL-C? So for example someone may have gone from 120, "down" to 111?
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that's how I read it
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I think the fact that these subjects were healthy (without metabolic disease) changes the outcome when compared with, for example, the biggest loser follow up. When insulin-resistance is not in the picture, everything changes.
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