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TamarHaspel's profile
Tamar Haspel
Tamar Haspel
Tamar Haspel
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@TamarHaspel

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Tamar HaspelVerified account

@TamarHaspel

Oyster farmer. James Beard winning Washington Post columnist. General nuisance.

Cape Cod
washingtonpost.com/people/tamar-h…
Joined November 2009

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    Tamar Haspel‏Verified account @TamarHaspel 29 Aug 2019

    All of you on Nutrition Twitter probably know the CALERIE trial, which got subjects to cut calories (aiming for 25%) for 2 years. Today, they published the cardio/metabolic indicators they measured in the study. A couple of notable things about this. 1/ https://www.sciencedirect.com/science/article/pii/S2213858719301512 …pic.twitter.com/SjkazaW2La

    9:48 AM - 29 Aug 2019
    • 18 Retweets
    • 62 Likes
    • Rantheman bukan gina lollobrigida Harry Saunders earl grey stan Chris Dave Bridges Richard Maguire Val Giddings Mohammed Mar'ae Asiri
    3 replies 18 retweets 62 likes
      1. New conversation
      2. Tamar Haspel‏Verified account @TamarHaspel 29 Aug 2019

        First is that all these measurements were clearly labeled "exploratory" and pre-registered as such. Yay!https://clinicaltrials.gov/ct2/show/NCT00427193 …

        1 reply 0 retweets 5 likes
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      3. Tamar Haspel‏Verified account @TamarHaspel 29 Aug 2019

        But it got me to look at the earlier paper, which reported weight loss and change in resting metabolism. Remarkably, subjects maintained a loss of 10% of body weight over 2 years. This is WAY better than most diet results. https://academic.oup.com/biomedgerontology/article/70/9/1097/2949096 …pic.twitter.com/dbklAJ1y0F

        2 replies 1 retweet 4 likes
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      4. Tamar Haspel‏Verified account @TamarHaspel 29 Aug 2019

        OK! That's pretty good. And researchers also measured resting metabolism. This is key, since your body tries to hang on to the weight you're trying to lose by lowering your resting metabolism. See @KevinH_PhD's work on Biggest Loser participants: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989512/ …pic.twitter.com/llMCRRF13R

        2 replies 1 retweet 4 likes
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      5. Tamar Haspel‏Verified account @TamarHaspel 29 Aug 2019

        Metabolic rate of course goes down when you lose weight because your body is smaller and needs less energy. But the crucial question is whether it goes down MORE than the weight loss would predict. And it does. But not much, in this case.pic.twitter.com/szYeW7PlaS

        2 replies 5 retweets 13 likes
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      6. Tamar Haspel‏Verified account @TamarHaspel 29 Aug 2019

        After losing 10% of body weight, metabolism was about 40 calories/day lower than the model predicted, compared to about 20 for the control group. And it's not the first to show a relatively small metabolic penalty.https://www.washingtonpost.com/news/wonk/wp/2016/05/05/why-the-weight-loss-study-everyone-has-been-sharing-is-kind-of-misleading/ …

        1 reply 1 retweet 6 likes
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      7. Tamar Haspel‏Verified account @TamarHaspel 29 Aug 2019

        So, lessons from CALERIE: - Cutting calories, rather than focusing on macronutrients, can be a successful weight loss strategy. - The metabolic penalty that is a big factor in weight regain is often quite small - Three cheers for pre-registration! OK I'm done now.

        3 replies 2 retweets 28 likes
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      8. End of conversation
      1. New conversation
      2. BiotechObserver‏ @BiotechObserver 29 Aug 2019
        Replying to @TamarHaspel

        Am I reading this correctly that losing 10% of bodyweight resulted in only about -9 mg/dL in LDL-C? So for example someone may have gone from 120, "down" to 111?

        1 reply 0 retweets 1 like
      3. Tamar Haspel‏Verified account @TamarHaspel 29 Aug 2019
        Replying to @BiotechObserver

        that's how I read it

        1 reply 0 retweets 2 likes
      4. Show replies
      1. Diego Peñailillo Güenante‏ @nachX 29 Aug 2019
        Replying to @TamarHaspel

        I think the fact that these subjects were healthy (without metabolic disease) changes the outcome when compared with, for example, the biggest loser follow up. When insulin-resistance is not in the picture, everything changes.

        0 replies 0 retweets 4 likes
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